Absence of effect of trimethoprim-sulfamethoxazole on pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus

被引：8
作者：
Canas, E
Pachon, J
GarciaPesquera, F
Castillo, JR
Viciana, P
Cisneros, JM
JimenezMejias, ME
机构：
[1] HOSP UNIV VIRGEN ROCIO,INFECT DIS UNIT,E-41013 SEVILLE,SPAIN
[2] HOSP UNIV VIRGEN ROCIO,DEPT NUCL MED,E-41013 SEVILLE,SPAIN
[3] HOSP UNIV VIRGEN ROCIO,CLIN PHARMACOL UNIT,E-41013 SEVILLE,SPAIN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 01期
关键词：
D O I：
10.1128/AAC.40.1.230
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfamethoxazole by oral administration. ZDV areas under the concentration-time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.69 +/- 0.64 mu g . h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.74 +/- 0.66 liters/h/kg, respectively.
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页码：230 / 233
页数：4
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