Bioactive chemical constituents from Curcuma caesia Roxb. rhizomes and inhibitory effect of curcuzederone on the migration of triple-negative breast cancer cell line MDA-MB-231

被引：24
作者：
Al-Amin, Mohammad [1 ]
Eltayeb, Nagla Mustafa [1 ,2 ]
Khairuddean, Melati [3 ]
Salhimi, Salizawati Muhamad [1 ]
机构：
[1] Univ Sains Malaysia, Sch Pharmaceut Sci, Discipline Pharmaceut Chem, George Town, Penang, Malaysia
[2] Natl Res Ctr, Trop Med Res Inst, Khartoum, Sudan
[3] Univ Sains Malaysia, Sch Chem Sci, George Town, Penang, Malaysia
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 18期
关键词：
Curcuma caesia Roxb; cell viability assay; bioactive chemical constituents; cell migration; curcuzederone; breast cancer cell lines;
D O I：
10.1080/14786419.2019.1690489
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Rhizomes of Curcuma caesia are traditionally used to treat cancer in India. The aim is to isolate chemical constituents from C. caesia rhizomes through bioassay-guided fractionation. The extract, hexanes and chloroform fractions showed effect on MCF-7 and MDA-MB-231cells in cell viability assay. The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7), dehydrocurdione (8) from hexanes fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1 (10), 4-diepoxide (11), wenyujinin B (12), alismoxide (13), aerugidiol (14), zedoarolide B (15), zedoalactone B (16), zedoarondiol (17), isozedoarondiol (18) from chloroform fraction. This is first report of compounds 2, 9-13, 15-18 from C. caesia. The study demonstrated compounds 1-4 and 10 are the bioactive compounds. The effect of curcuzederone (10) on MDA-MB-231 cell migration showed significant inhibition in scratch and Transwell migration assays. The results revealed that curcuzederone could be a promising drug to treat cancer.
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页码：3166 / 3170
页数：5
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