The role of natriuretic peptide-guided therapy in heart failure management

被引：0
|
作者：
Kern, T. [1 ]
Kedan, I.
Kimchi, A. [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
NEW INSIGHTS INTO MECHANISMS AND MANAGEMENT OF HEART DISEASE | 2013年
关键词：
Heart failure; natriuretic peptide; guided therapy; BNP; NT-proBNP; MORBIDITY; TRIAL; CARE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Natriuretic peptide has been validated as a useful biomarker in the diagnosis of heart failure. Its role in guiding medical management of heart failure is not well established. Our objective is to determine if natriuretic peptide-guided therapy is associated with improved outcomes for heart failure patients. We conducted a PubMed search to identify prospective randomized controlled trials evaluating natriuretic peptide-guided therapy. 12 trials (2,688 patients) comparing natriuretic peptide-guided therapy to standard therapy for heart failure patients were identified, with follow-up times ranging from 3 months to 3 years. Our data indicates that natriuretic peptide levels and all-cause mortality rates do not appear to benefit from natriuretic peptide-guided therapy compared to standard therapy. However, a decreased rate of cardiovascular events does appear to be associated with natriuretic peptide-guided therapy.
引用
收藏
页码：127 / 130
页数：4
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