Coupling Electrochemistry with Probe Electrospray Ionization Mass Spectrometry

被引：18

作者：

Cai, Yi ^{[1
]}

Liu, Pengyuan ^{[1
]}

Held, Michael A. ^{[1
]}

Dewald, Howard D. ^{[1
]}

Chen, Hao ^{[1
]}

机构：

[1] Ohio Univ, Ctr Intelligent Chem Instrumentat, Dept Chem & Biochem, Edison Biotechnol Inst, Athens, OH 45701 USA

来源：

CHEMPHYSCHEM | 2016年 / 17卷 / 08期

基金：

美国国家科学基金会;

关键词：

analytical methods; electrochemical reactions; mass spectrometry; probe electrospray ionization; ionic liquids; LIQUID-CHROMATOGRAPHY; ROOM-TEMPERATURE; DRUG-METABOLISM; IONIC LIQUIDS; PROTEIN; MS; IDENTIFICATION; ONLINE; FRACTIONATION; REACTIVITY;

D O I：

10.1002/cphc.201600033

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new coupling of electrochemistry with mass spectrometry (MS) using probe electrospray ionization (PESI) is presented. Due to the high salt tolerance of PESI, the detection of electrochemical reaction products in room-temperature ionic liquids (RTILs) is realized for the first time. Furthermore, PESI-MS allows the analysis of electrochemical reaction products on different or multiple electrode surfaces. In addition, peptides and proteins fractionated through isoelectric focusing (IEF) in the presence of an external electric field can also be directly analyzed by using PESI-MS, suggesting a new and rapid characterization means for the IEF technique. This study reveals the versatility of EC/PESI-MS, which could have an impact in electrochemistry and bioanalysis fields.

引用

页码：1104 / 1108

页数：5

共 44 条

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