Formal (3+4)-Annulation of Propargylic p-Quinone Methides with 2-Indolylmethanols: Synthesis of Polysubstituted Indole-Fused Oxepines

被引：21

作者：

Qiu, Zong-Wang ^{[1
]}

Li, Bao Qiong ^{[1
]}

Liu, Hong-Fu ^{[1
]}

Zhu, Zhi-Qiang ^{[1
]}

Pan, Han-Peng ^{[1
]}

Feng, Na ^{[1
]}

Ma, Ai-Jun ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Zhang, Xiang-Zhi ^{[1
]}

机构：

[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 11期

关键词：

STRATEGIES;

D O I：

10.1021/acs.joc.1c00484

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Bronsted acid catalyzed 1,8-addition mediated (3 + 4)-annulation of in situ generated propargylic p-quinone methides with 2-indolylmethanols is described. This method provides a convenient and mild approach to structurally interesting and synthetically important polysubstituted indole-fused oxepines in high yields. Moreover, 2-indolylmethanols as four-atom synthons in the (3 + 4)-annulations under Bronsted acid conditions have been explored for the first time.

引用

页码：7490 / 7499

页数：10

共 44 条

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