A NEW CHALCONE AND ANTIOXIDANT CONSTITUENTS OF Glycyrrhiza glabra

被引：13

作者：

Chen, Jih-Jung ^{[1
,2
]}

Cheng, Ming-Jen ^{[3
]}

Shu, Chih-Wen ^{[4
]}

Sung, Ping-Jyun ^{[5
]}

Lim, Yun-Ping ^{[6
]}

Cheng, Lin-Yang ^{[7
]}

Wang, Sin-Ling ^{[7
]}

Chen, Li-Chai ^{[8
,9
]}

机构：

[1] Natl Yang Ming Univ, Sch Pharmaceut Sci, Fac Pharnacy, Taipei 112, Taiwan

[2] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[3] FIRDI, BCRC, Hsinchu 300, Taiwan

[4] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan

[5] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[6] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[7] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[8] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[9] Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Dept Pharm, Kaohsiung 813, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 04期

关键词：

Glycyrrhiza glabra; chalcone; glycyglabrone; antioxidant activity;

D O I：

10.1007/s10600-017-2077-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new chalcone, glycyglabrone (1), has been isolated from the roots of Glycyrrhiza glabra, together with three known compounds, licoagrochalcone B (2), licochalcone C (3), and kanzonol Y (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Glycyglabrone (1) and licochalcone C (3) exhibited potent free radical scavenging activity, with IC0.200 values of 4.6 +/- 0.6 and 8.2 +/- 0.9 mu M, respectively, in the diphenylpicrylhydrazyl radical (DPPH) decoloration assay.

引用

页码：632 / 634

页数：3

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