A new phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla

被引：48

作者：

Chen, Jih-Jung ^{[1
]}

Huang, Sheng-Shiou ^{[1
]}

Liao, Chang-Hui ^{[2
]}

Wei, Dau-Chang ^{[1
]}

Sung, Ping-Jyun ^{[3
]}

Wang, Tai-Chi ^{[1
]}

Cheng, Ming-Jen ^{[4
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Yanpu Shiang 907, Pingtung, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[4] FIRDI, BCRC, Hsinchu 300, Taiwan

来源：

FOOD CHEMISTRY | 2010年 / 120卷 / 02期

关键词：

Swietenia macrophylla; Meliaceae; Structure elucidation; Phragmalin-type limonoid; Anti-inflammatory activity; MAHAGONI JACQ; DERIVATIVES; NEUTROPHILS; TETRANORTRITERPENOIDS; SESQUITERPENES; LEUKOCYTES; SEEDS;

D O I：

10.1016/j.foodchem.2009.09.093

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The fruit of Swietenia macrophylla is commercially used in healthcare products for the improvement of blood circulation and skin condition. A new phragmalin-type limonoid, 6-0-acety1-3'-demethylswietephragmin E (1), has been isolated from the fruit of S. macrophylla, together with 16 known compounds. The structure of this new compound was determined through spectroscopic and MS analyses. 6-O-Acetyl-3'-demethylswietephragmin E (1), 3,6-O,O-diacetylswietenolide (5), 3-O-tigloylswietenolide (6). 3-O-tigloyl-6-O-acetylswietenolide (8), swietemahonin E (9), and 6-O-acetylswietemahonin G (10) exhibited inhibition (IC(50) <= 35.7 mu M) Of Superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylaianine (fMLP). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：379 / 384

页数：6

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