Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjogren's syndrome

被引:22
作者
Blokland, Sofie L. M. [1 ,2 ]
van den Hoogen, Lucas L. [1 ,2 ]
Leijten, Emmerik F. A. [1 ,2 ]
Hartgring, Sarita A. Y. [1 ,2 ]
Fritsch, Ruth [1 ,3 ,4 ]
Kruize, Aike A. [1 ]
van Roon, Joel A. G. [1 ,2 ]
Radstake, Timothy R. D. J. [1 ,2 ]
机构
[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Immunol, Lab Translat Immunol, Utrecht, Netherlands
[3] Sigmund Freud Private Univ, Fac Med, Vienna, Austria
[4] Hanusch Hosp WGKK&AUVA Trauma Ctr Meidling, Ludwig Boltzmann Inst Osteol, Hanusch Hosp, Med Dept 1, Vienna, Austria
关键词
systemic lupus erythematosus; Sjogren's syndrome; innate lymphoid cells; type I interferon; Fas; RECEPTOR; INTERLEUKIN-7; INFECTION; IL-22;
D O I
10.1093/rheumatology/kez116
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The role of innate lymphoid cells (ILCs) in the pathophysiology of rheumatic diseases is emerging. Evidence from animal studies implicate type I IFN, produced by plasmacytoid dendritic cells, to be involved in regulating the survival of group 2 and group 3 ILCs (ILC2s and ILC3s) via the upregulation of Fas (CD95) expression. For the first time, we explored the frequency and phenotype of circulating ILCs in SLE and primary Sjogren's syndrome (pSS) in relationship to the IFN signature. Methods. Frequencies and phenotypes of ILC subsets and plasmacytoid dendritic cells were assessed by flow cytometry in peripheral blood of patients with SLE (n = 20), pSS (n = 20) and healthy controls (n = 17). Patients were stratified by the presence or absence of an IFN signature as assessed by RT-qPCR on circulating mononuclear cells. Results. ILC1 frequencies were increased in peripheral blood of patients with SLE as compared with healthy controls and correlate with disease activity in pSS patients. Overall, the frequencies of ILC2s or ILC3s did not differ between patients with SLE, pSS and healthy controls. However, patients with a high type I IFN signature expressed elevated levels of Fas on ILC2s and ILC3s, which coincided with decreased frequencies of these cells in blood. Conclusion. The presence of a type I IFN signature is related to Fas expression and frequencies of circulating ILC2s and ILC3s in patients with SLE and pSS, potentially altering the homeostatic balance of ILCs.
引用
收藏
页码:1740 / 1745
页数:6
相关论文
共 24 条
[1]   Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus [J].
Badot, Valerie ;
Luijten, Remco K. M. A. C. ;
van Roon, Joel A. ;
Depresseux, Genevieve ;
Aydin, Selda ;
Van den Eynde, Benoit J. ;
Houssiau, Frederic A. ;
Lauwerys, Bernard R. .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (03) :453-456
[2]   IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs [J].
Barone, Francesca ;
Nayar, Saba ;
Campos, Joana ;
Cloake, Thomas ;
Withers, David R. ;
Toellner, Kai-Michael ;
Zhang, Yang ;
Fouser, Lynette ;
Fisher, Benjamin ;
Bowman, Simon ;
Rangel-Moreno, Javier ;
Garcia-Hernandez, Maria de la Luz ;
Randall, Troy D. ;
Lucchesi, Davide ;
Bombardieri, Michele ;
Pitzalis, Costantino ;
Luther, Sanjiv A. ;
Buckley, Christopher D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (35) :11024-11029
[3]   Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression [J].
Brkic, Zana ;
Maria, Naomi I. ;
van Helden-Meeuwsen, Cornelia G. ;
van de Merwe, Joop P. ;
van Daele, Paul L. ;
Dalm, Virgil A. ;
Wildenberg, Manon E. ;
Beumer, Wouter ;
Drexhage, Hemmo A. ;
Versnel, Marjan A. .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (05) :728-735
[4]   Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's syndrome [J].
Ciccia, Francesco ;
Guggino, Giuliana ;
Rizzo, Aroldo ;
Ferrante, Angelo ;
Raimondo, Stefania ;
Giardina, AnnaRita ;
Dieli, Francesco ;
Campisi, Giuseppina ;
Alessandro, Riccardo ;
Triolo, Giovanni .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (02) :295-301
[5]   Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells [J].
Duerr, Claudia U. ;
McCarthy, Connor D. A. ;
Mindt, Barbara C. ;
Rubio, Manuel ;
Meli, Alexandre P. ;
Pothlichet, Julien ;
Eva, Megan M. ;
Gauchat, Jean-Francois ;
Qureshi, Salman T. ;
Mazer, Bruce D. ;
Mossman, Karen L. ;
Malo, Danielle ;
Gamero, Ana M. ;
Vidal, Silvia M. ;
King, Irah L. ;
Sarfati, Marika ;
Fritz, Joerg H. .
NATURE IMMUNOLOGY, 2016, 17 (01) :65-+
[6]   Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus [J].
Furie, Richard ;
Khamashta, Munther ;
Merrill, Joan T. ;
Werth, Victoria P. ;
Kalunian, Kenneth ;
Brohawn, Philip ;
Illei, Gabor G. ;
Drappa, Jorn ;
Wang, Liangwei ;
Yoo, Stephen .
ARTHRITIS & RHEUMATOLOGY, 2017, 69 (02) :376-386
[7]   Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs [J].
Gasteiger, Georg ;
Fan, Xiying ;
Dikiy, Stanislav ;
Lee, Sue Y. ;
Rudensky, Alexander Y. .
SCIENCE, 2015, 350 (6263) :981-985
[8]   Interleukin-25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjogren's Syndrome [J].
Guggino, Giuliana ;
Lin, Xiang ;
Rizzo, Aroldo ;
Xiao, Fan ;
Saieva, Laura ;
Raimondo, Stefania ;
Di Liberto, Diana ;
Candore, Giuseppina ;
Ruscitti, Piero ;
Cipriani, Paola ;
Giacomelli, Roberto ;
Dieli, Francesco ;
Alessandro, Riccardo ;
Triolo, Giovanni ;
Lu, Liwei ;
Ciccia, Francesco .
ARTHRITIS & RHEUMATOLOGY, 2018, 70 (08) :1265-1275
[9]   High soluble IL-7 receptor expression in Sjogren's syndrome identifies patients with increased immunopathology and dryness [J].
Hillen, M. R. ;
Blokland, S. L. M. ;
Risselada, A. P. ;
Bikker, A. ;
Lauwerys, B. R. ;
Kruize, A. A. ;
Radstake, T. R. D. J. ;
van Roon, J. A. G. .
ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (09) :1735-1736
[10]   Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression [J].
Kloverpris, Henrik N. ;
Kazer, Samuel W. ;
Mjosberg, Jenny ;
Mabuka, Jenniffer M. ;
Wellmann, Amanda ;
Ndhlovu, Zaza ;
Yadon, Marisa C. ;
Nhamoyebonde, Shepherd ;
Muenchhoff, Maximilian ;
Simoni, Yannick ;
Andersson, Frank ;
Kuhn, Warren ;
Garrett, Nigel ;
Burgers, Wendy A. ;
Kamya, Philomena ;
Pretorius, Karyn ;
Dong, Krista ;
Moodley, Amber ;
Newell, Evan W. ;
Kasprowicz, Victoria ;
Karim, Salim S. Abdool ;
Goulder, Philip ;
Shalek, Alex K. ;
Walker, Bruce D. ;
Ndung'u, Thumbi ;
Leslie, Alasdair .
IMMUNITY, 2016, 44 (02) :391-405