A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

被引：0
|
作者：
Zhang Jie [1 ]
Wang Chuan-Xi [2 ]
Song Xiao-Jun [1 ]
Li Shuang [1 ]
Zhao Huan [2 ]
Chen Guo-Dong [2 ]
Hu Dan [2 ]
Gao Hao [1 ,2 ]
Yao Xin-Sheng [2 ]
机构：
[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Tirucallane triterpenoid; Epimers; Picrasma quassioides; AChE inhibitory activity; Cytotoxicity; Antimicrobial activity;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1 and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
引用
收藏
页码：906 / 911
页数：6
相关论文
共 50 条
  • [31] Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity
    Jiang, Mei-Xiang
    Zhou, Ying-Jun
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (11) : 1009 - 1012
  • [32] Enantiomeric β-carboline dimers from Picrasma quassioides and their anti-hepatoma potential
    Zhao, Wen-Yu
    Zhou, Wei-Yu
    Chen, Jing-Jie
    Yao, Guo-Dong
    Lin, Bin
    Wang, Xiao-Bo
    Huang, Xiao-Xiao
    Song, Shao-Jiang
    PHYTOCHEMISTRY, 2019, 159 : 39 - 45
  • [33] Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects
    Chen Qian-wen
    Ye Xiao
    Liu Xiao-qian
    Liang Yao-hua
    Feng Wei-hong
    Li Chun
    Wang Zhi-min
    PHYTOCHEMISTRY, 2022, 193
  • [34] Quassinoids with Insecticidal Activity against Diaphorina citri Kuwayama and Neuroprotective Activities from Picrasma quassioides
    He, Cui
    Wang, Yaqi
    Yang, Tingmi
    Wang, Hengshan
    Liao, Haibing
    Liang, Dong
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 68 (01) : 117 - 127
  • [35] A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata
    Simone Veronique Fannang
    Victor Kuete
    Celine Mbazoa Djama
    Marlise Diane J.Dongfack
    Jean Duplex Wansi
    Francois Tillequin
    Elisabeth Seguin
    Elizabeth Chosson
    Jean Wandji
    ChineseChemicalLetters, 2011, 22 (02) : 171 - 174
  • [36] A new friedelane triterpenoid and saponin with moderate antimicrobial. activity from the stems of Drypetes laciniata
    Fannang, Simone Veronique
    Kuete, Victor
    Djama, Celine Mbazoa
    Dongfack, Marlise Diane J.
    Wansi, Jean Duplex
    Tillequin, Francois
    Seguin, Elisabeth
    Chosson, Elizabeth
    Wandji, Jean
    CHINESE CHEMICAL LETTERS, 2011, 22 (02) : 171 - 174
  • [37] Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production
    Kong, Lingbo
    Wang, Biao
    Yang, Xiaobin
    Guo, Hua
    Zhang, Ke
    Zhu, Ziqi
    Liu, Jijun
    Hao, Dingjun
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (04) : 1425 - 1435
  • [38] ISOLATION OF 4-HYDROXY-5-METHOXYCANTHIN-6-ONE FROM PICRASMA-QUASSIOIDES AND REVISION OF A PREVIOUSLY REPORTED STRUCTURE
    LIU, J
    DAVIDSON, RS
    VANDERHEIJDEN, R
    VERPOORTE, R
    HOWARTH, OW
    LIEBIGS ANNALEN DER CHEMIE, 1992, (09): : 987 - 988
  • [39] Enantiomeric neolignans from Picrasma quassioides exhibit distinctive cytotoxicity on hepatic carcinoma cells through ROS generation and apoptosis induction
    Lou, Li-Li
    Yao, Guo-Dong
    Wang, Jie
    Zhao, Wen-Yu
    Wang, Xiao-Bo
    Huang, Xiao-Xiao
    Song, Shao-Jiang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (08) : 1263 - 1268
  • [40] Fingerprinting and simultaneous determination of alkaloids in Picrasma quassioides from different locations by high performance liquid chromatography with photodiode array detection
    Liao, Hui-Jun
    Lai, Zheng-Quan
    Su, Ji-Yan
    Yi, Yu-Yang
    Li, Yu-Cui
    Lai, Xiao-Ping
    Su, Zi-Ren
    Lin, Zhi-Xiu
    JOURNAL OF SEPARATION SCIENCE, 2012, 35 (17) : 2193 - 2202
12345