A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

被引：0

作者：

Zhang Jie ^{[1
]}

Wang Chuan-Xi ^{[2
]}

Song Xiao-Jun ^{[1
]}

Li Shuang ^{[1
]}

Zhao Huan ^{[2
]}

Chen Guo-Dong ^{[2
]}

Hu Dan ^{[2
]}

Gao Hao ^{[1
,2
]}

Yao Xin-Sheng ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Tirucallane triterpenoid; Epimers; Picrasma quassioides; AChE inhibitory activity; Cytotoxicity; Antimicrobial activity;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1 and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.

引用

页码：906 / 911

页数：6

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