Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines

被引：82

作者：

Zhang, Hong-Yu ^{[1
]}

Mao, Liu-Liang ^{[1
]}

Yang, Bin ^{[1
]}

Yang, Shang-Dong ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 19期

关键词：

MONOSUBSTITUTED PHOSPHINIC ACIDS; ALKENE CARBOAMINATION REACTIONS; P BOND CONSTRUCTION; C-H BONDS; UNACTIVATED ALKENES; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLE SYNTHESIS; CONJUGATED DIENES; PALLADIUM;

D O I：

10.1039/c4cc10267c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed. The reaction employs cheap copper as the catalyst and K2S2O8 as the oxidant under mild conditions. Various alkenes and P-radical precursors are compatible with this transformation. Preliminary mechanistic studies reveal that the addition of the P-radical may initiate the reaction, and then oxidative cyclization may be achieved to afford the desired product.

引用

页码：4101 / 4104

页数：4

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