Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry

被引：1
作者：
Paparin, JL
Crévisy, C
Toupet, L
Grée, R
机构：
[1] ENSCR, UMR CNRS 6052, Lab Synth & Activat Biomol, F-35042 Rennes, France
[2] Univ Rennes 1, Grp Mat Condensee & Mat, F-35042 Rennes, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 23期
关键词：
cycloadditions; alkaloids; combinatorial chemistry; scaffolds; tropanes;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and alpha,alpha'-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.
引用
收藏
页码：3909 / 3918
页数：10
相关论文
共 50 条
[41]   From solution-phase studies to solid-phase synthesis: A new indole based scaffold for combinatorial chemistry [J].
Orain, D ;
Koch, G ;
Giger, R .
CHIMIA, 2003, 57 (05) :255-261
[42]   Discovery, combinatorial chemistry and a new selective CO-oxidation catalyst [J].
Maier, WF ;
Saalfrank, J .
CHEMICAL ENGINEERING SCIENCE, 2004, 59 (22-23) :4673-4678
[43]   Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: An old parameter - New insights [J].
Cohen, Y ;
Avram, L ;
Frish, L .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (04) :520-554
[44]   Drug discovery by combinatorial chemistry - The development of a novel method for the rapid synthesis of single compounds [J].
Terrett, NK ;
Gardner, M ;
Gordon, DW ;
Kobylecki, RJ ;
Steele, J .
CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (12) :1917-1920
[45]   Computational design of new molecular scaffolds for medicinal chemistry, part II: generalization of analog series-based scaffolds [J].
Dimova, Dilyana ;
Stumpfe, Dagmar ;
Bajorath, Juergen .
FUTURE SCIENCE OA, 2018, 4 (02)
[46]   New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization [J].
Levchenko, Kostiantyn ;
Menshykova, Daria ;
Pokhodylo, Nazariy .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2025, 29 (07) :1792-1808
[47]   Synthesis of macrocyclic scaffolds from natural products and their utilization for solid-phase chemistry [J].
Grosche, P ;
Akyel, KG ;
Marzinzik, AL .
SYNTHESIS-STUTTGART, 2005, (12) :2015-2021
[48]   A "single-sample concept" (SSC): A new approach to the combinatorial chemistry of inorganic materials [J].
Hullinger, J ;
Awan, MA .
CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (19) :4694-4702
[49]   Microwave-Assisted Fluorous Multicomponent Reactions - A Combinatorial Chemistry Approach for Green Organic Synthesis [J].
Kadam, Asha ;
Zhang, Zijuan ;
Zhang, Wei .
CURRENT ORGANIC SYNTHESIS, 2011, 8 (02) :295-309
[50]   Targeting Oncogenic Protein-Protein Interactions by Diversity Oriented Synthesis and Combinatorial Chemistry Approaches [J].
Tzakos, Andreas G. ;
Fokas, Demosthenes ;
Johannes, Charlie ;
Moussis, Vassilios ;
Hatzimichael, Eleftheria ;
Briasoulis, Evangelos .
MOLECULES, 2011, 16 (06) :4408-4427
12345