Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry

被引：1
|
作者：
Paparin, JL
Crévisy, C
Toupet, L
Grée, R
机构：
[1] ENSCR, UMR CNRS 6052, Lab Synth & Activat Biomol, F-35042 Rennes, France
[2] Univ Rennes 1, Grp Mat Condensee & Mat, F-35042 Rennes, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 23期
关键词：
cycloadditions; alkaloids; combinatorial chemistry; scaffolds; tropanes;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and alpha,alpha'-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.
引用
收藏
页码：3909 / 3918
页数：10
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