Thai silk fibroin gelation process enhancing by monohydric and polyhydric alcohols

被引：48

作者：

Kaewprasit, Kanyaluk ^{[1
]}

Kobayashi, Takaomi ^{[2
]}

Damrongsakkul, Siriporn ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Engn, Dept Chem Engn, Phaya Thai Rd, Bangkok 10330, Thailand

[2] Nagaoka Univ Technol, Dept Mat Sci & Technol, 1603-1 Kamitomioka, Nagaoka, Niigata 9402188, Japan

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 118卷

关键词：

Silk fibroin hydrogel; Gelation process; Alcohol enhancing; Monohydric alcohol; Polyhydric alcohol; Hydrophobic interaction; CONFORMATION TRANSITION KINETICS; TRANSFORM INFRARED-SPECTROSCOPY; PROTEIN SECONDARY STRUCTURES; CONTROLLED-RELEASE; IONIC LIQUIDS; WATER; SCAFFOLDS; TEMPERATURE; SURFACE; FILMS;

D O I：

10.1016/j.ijbiomac.2018.07.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silk fibroin hydrogel is an interesting natural material in various biomedical applications. However, the self assembled gelation takes a long time. In this work, different alcohol types are used as gelation enhancers for aqueous silk fibroin solution. Monohydric alcohols having carbon chain length from C1 to C4 and polyhydric alcohols with the number of mono- to tri- hydroxyl groups were used as the enhancers which are effective for rapid gelation. The addition of monohydric alcohol distinctively reduced the gelation time, comparing to the polyhydric alcohol. The gelation process is directly dependent on the polarity of alcohol and hydrophobicity. The alcohol mediated gelation imparts strong viscoelastic property and enhanced compressive modulus of resulting hydrogels. This is due to the effective formation of self-assembled beta sheet network of the silk fibroin chains facilitates the gelation process. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1726 / 1735

页数：10

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