Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol

被引：15

作者：

Hirano, Tsutomu ^{[1
]}

Kodera, Rieko ^{[1
]}

Hirashima, Takeshi ^{[1
]}

Suzuki, Natsuko ^{[1
]}

Aoki, Ema ^{[1
]}

Hosoya, Mitsuru ^{[1
]}

Oshima, Taito ^{[1
]}

Hayashi, Toshiyuki ^{[2
]}

Koba, Shinji ^{[3
]}

Ohta, Motoko ^{[4
]}

Satoh, Noriyuki ^{[4
]}

Ito, Yasuki ^{[4
]}

机构：

[1] Ebina Gen Hosp, Diabet Ctr, Kawaharaguchi 13200, Ebina, Kanagawa, Japan

[2] Yurakubashi Clin, Tokyo, Japan

[3] Showa Univ, Sch Dent, Dept Perioperat Med, Div Comprehens Internal Med, Tokyo, Japan

[4] Denka Co Ltd, R&D Dept, Niigata, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2022年 / 29卷 / 05期

关键词：

LDL triglycerides; Small dense LDL-cholesterol; Diabetes; Metabolic syndrome; Apolipoprotein B; CORONARY-ARTERY-DISEASE; CLINICAL-SIGNIFICANCE; HOMOGENEOUS ASSAY; HEPATIC LIPASE; RISK; DYSLIPIDEMIA; INSULIN;

D O I：

10.5551/jat.62789

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aims: Abnormal compositional changes in low-density lipoprotein (LDL) particles, such as triglyceride (TG) enrichment and size reduction, are common in patients with diabetes. Several cohort studies have demonstrated that LDL-TG and sdLDL-cholesterol (C) are sensitive biomarkers for predicting atherosclerotic cardiovascular diseases beyond LDL-C. Although sdLDL has been extensively studied, little is known about the properties of LDL-TG. We investigated similarities or differences between LDL-TG and sdLDL-C. Methods: Fasting plasma was obtained from 1,085 patients with type 2 diabetes who were enrolled in the diabetes regional cohort study (ViNA Cohort). LDL-TG and sdLDL-C concentrations were measured using a homogeneous assay established by us. In a subset of subjects, LDL-TG and sdLDL-C levels were measured postprandially or after treatment with lipid-lowering drugs. Results: In a quartile analysis, higher LDL-TG quartiles were associated with higher frequency of female and fibrate users, whereas sdLDL-C quartiles were associated with frequency of men, drinking, and metabolic syndrome-related measurements. Higher quartiles of LDL-TG/LDL-C were associated with smoking, drinking, fibrate users, and statin users. LDL-TG was significantly correlated with TG, LDL-C, sdLDL-C, and apolipoprotein (apo) B, with apoB being the primary determinant. LDL-TG correlated to high sensitive C-reactive protein (CRP) independently of other lipids. Mean LDL-TG did not change with fasting/non-fasting. Statin treatment reduced LDL-TG, whereas fibrates increased it, but these drugs reduced sdLDL-C equally. Conclusions: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.

引用

页码：762 / 774

页数：13

共 28 条

[11] Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease The Atherosclerosis Risk in Communities ( ARIC) Study [J].

Hoogeveen, Ron C. ;

Gaubatz, John W. ;

Sun, Wensheng ;

Dodge, Rhiannon C. ;

Crosby, Jacy R. ;

Jiang, Jennifer ;

Couper, David ;

Virani, Salim S. ;

Kathiresan, Sekar ;

Boerwinkle, Eric ;

Ballantyne, Christie M. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (05) :1069-1077

[12]

Hua Q, 2020, CARDIOVASC DIABETOL

[13] Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial [J].

Ishibashi, Shun ;

Yamashita, Shizuya ;

Arai, Hidenori ;

Araki, Eiichi ;

Yokote, Koutaro ;

Suganami, Hideki ;

Fruchart, Jean-Charles ;

Kodama, Tatsuhiko .

ATHEROSCLEROSIS, 2016, 249 :36-43

[14] Development and Population Results of a Fully Automated Homogeneous Assay for LDL Triglyceride [J].

Ito, Yasuki ;

Ohta, Motoko ;

Ikezaki, Hiroaki ;

Hirao, Yuhko ;

Machida, Asako ;

Schaefer, Ernst J. ;

Furusyo, Norihiro .

JOURNAL OF APPLIED LABORATORY MEDICINE, 2018, 2 (05) :746-756

[15] Development of a Homogeneous Assay for Measurement of Small Dense LDL Cholesterol [J].

Ito, Yasuki ;

Fujimura, Miki ;

Ohta, Motoko ;

Hirano, Tsutomu .

CLINICAL CHEMISTRY, 2011, 57 (01) :57-65

[16] RELATIONSHIP BETWEEN POSTHEPARIN PLASMA LIPASES AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IN DIFFERENT TYPES OF DIABETES [J].

LAAKSO, M ;

SARLUND, H ;

EHNHOLM, C ;

VOUTILAINEN, E ;

ARO, A ;

PYORALA, K .

DIABETOLOGIA, 1987, 30 (09) :703-706

[17] Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease -: The Ludwigshafen Risk and Cardiovascular Health study [J].

März, W ;

Scharnagl, H ;

Winkler, K ;

Tiran, A ;

Nauck, M ;

Boehm, BO ;

Winkelmann, BR .

CIRCULATION, 2004, 110 (19) :3068-3074

[18] Low-Density Lipoprotein Triglycerides Widening the Atherogenic Landscape in CVD Risk Assessment [J].

Miller, Michael .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (02) :170-172

[19]

Packard CJ, 2003, BIOCHEM SOC T, V31, P1066

[20] The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates [J].

Rizzo, Manfredi ;

Berneis, Kaspar .

CURRENT MEDICAL RESEARCH AND OPINION, 2007, 23 (05) :1103-1111

← 1 2 3 →