Analysis of chemical composition of polysaccharides from Poria cocos Wolf and its anti-tumor activity by NMR spectroscopy

被引：59
作者：
Ke RuiDian [1 ]
Lin ShunFa [1 ]
Chen Yi [1 ]
Ji ChuRong [2 ]
Shu QiaGuang [3 ]
机构：
[1] Shantou Univ, Dept Radiol, Affiliated Hosp 1, Coll Med, Shantou 515041, Guangdong, Peoples R China
[2] Shantou Univ, Dept Obstet, Affiliated Hosp 1, Coll Med, Shantou 515041, Guangdong, Peoples R China
[3] Second People Hosp ZhongShan, Dept TB, Guangzhou, Guangdong, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2010年 / 80卷 / 01期
关键词：
Anti-tumor activity; Polysaccharide from Poria cocos Wolf; GC-MS; NMR spectroscopy; Chemical structure; ACTIVATION;
D O I：
10.1016/j.carbpol.2009.10.063
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this Study, we extracted the polysaccharide from Poria cocos Wolf and examined its chemical components using gas chromatography-mass spectrophotometer (GC-MS) and fourier transform infrared (FT-IR) spectra. Then its anti-tumor effects was investigated via in vivo assays. Chemical analysis revealed that the polysaccharide was composed of ribose, arabinose, xylose, mannose, glucose, and galactose in the molar contents of 1.49, 1.17, 0.62, 10.34, 86.39 and 1.31 mu M. respectively, and their corresponding mole percentages were 1.6%. 1.09%, 0.54%. 11.3%, 85.9%, and 1.01%, respectively. After 7 weeks of feeding, the polysaccharide significantly inhibited tumor cells growth and increased Serum Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities in rats. These results indicate that the polysaccharide possessed strong anti-tumor activity. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：31 / 34
页数：4
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