Characterization of murine gammaherpesvirus 68 glycoprotein B

被引：28

作者：

Lopes, FB ^{[1
]}

Colaco, S ^{[1
]}

May, JS ^{[1
]}

Stevenson, PG ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 23期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/JVI.78.23.13370-13375.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine gammaherpesvirus 68 (MHV-68) glycoprotein B (gB) was identified in purified virions by immunoblotting, immunoprecipitation, and immunoelectron microscopy. It was synthesized as a 120-kDa precursor in infected cells and cleaved into 65-kDa and 55-kDa disulfide-linked subunits close to the time of virion release. The N-linked glycans on the cleaved, virion gB remained partially endoglycosidase H sensitive. The processing of MHV-68 gB therefore appears similar to that of Kaposi's sarcoma-associated herpesvirus gB and human cytomegalovirus gB.

引用

页码：13370 / 13375

页数：6

共 34 条

[1] Integrin α3β1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells [J].

Akula, SM ;

Pramod, NP ;

Wang, FZ ;

Chandran, B .

CELL, 2002, 108 (03) :407-419

[2] Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moieties [J].

Akula, SM ;

Pramod, NP ;

Wang, FZ ;

Chandran, B .

VIROLOGY, 2001, 284 (02) :235-249

[3] BOVINE AND MOUSE SERUM BETA-INHIBITORS OF INFLUENZA-A VIRUSES ARE MANNOSE-BINDING LECTINS [J].

ANDERS, EM ;

HARTLEY, CA ;

JACKSON, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4485-4489

[4] Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments [J].

Baghian, A ;

Luftig, M ;

Black, JB ;

Meng, YX ;

Pau, CP ;

Voss, T ;

Pellett, PE ;

Kousoulas, KG .

VIROLOGY, 2000, 269 (01) :18-25

[5] PRIMATE CYTOMEGALOVIRUS GLYCOPROTEINS - LECTIN-BINDING PROPERTIES AND SENSITIVITIES TO GLYCOSIDASES [J].

BENKO, DM ;

GIBSON, W .

JOURNAL OF VIROLOGY, 1986, 59 (03) :703-713

[6] MHC class I ubiquitination by a viral PHD/LAP finger protein [J].

Boname, JM ;

Stevenson, PG .

IMMUNITY, 2001, 15 (04) :627-636

[7] Identification of proteins associated with murine gammaherpesvirus 68 virions [J].

Bortz, E ;

Whitelegge, JP ;

Jia, QM ;

Zhou, ZH ;

Stewart, JP ;

Wu, TT ;

Sun, R .

JOURNAL OF VIROLOGY, 2003, 77 (24) :13425-13432

[8] Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo [J].

De Lima, BD ;

May, JS ;

Stevenson, PG .

JOURNAL OF VIROLOGY, 2004, 78 (10) :5103-5112

[9] CLONING AND MOLECULAR CHARACTERIZATION OF THE MURINE HERPESVIRUS 68 GENOME [J].

EFSTATHIOU, S ;

HO, YM ;

MINSON, AC .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :1355-1364

[10] Latent murine γ-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages [J].

Flaño, E ;

Husain, SM ;

Sample, JT ;

Woodland, DL ;

Blackman, MA .

JOURNAL OF IMMUNOLOGY, 2000, 165 (02) :1074-1081

← 1 2 3 4 →