The pachytene checkpoint

被引：400
作者：
Roeder, GS
Bailis, JM
机构：
[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
TRENDS IN GENETICS | 2000年 / 16卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0168-9525(00)02080-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.
引用
收藏
页码：395 / 403
页数：9
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