The pachytene checkpoint

被引：397
作者：
Roeder, GS
Bailis, JM
机构：
[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
TRENDS IN GENETICS | 2000年 / 16卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0168-9525(00)02080-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.
引用
收藏
页码：395 / 403
页数：9
相关论文
共 73 条
[1]   REGULATION OF P34CDC28 TYROSINE PHOSPHORYLATION IS NOT REQUIRED FOR ENTRY INTO MITOSIS IN SACCHAROMYCES-CEREVISIAE [J].
AMON, A ;
SURANA, U ;
MUROFF, I ;
NASMYTH, K .
NATURE, 1992, 355 (6358) :368-371
[2]   Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins [J].
Bailis, JM ;
Smith, AV ;
Roeder, GS .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) :4838-4848
[3]   Pachytene exit controlled by reversal of Mek1-dependent phosphorylation [J].
Bailis, JM ;
Roeder, GS .
CELL, 2000, 101 (02) :211-221
[4]   Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein [J].
Bailis, JM ;
Roeder, GS .
GENES & DEVELOPMENT, 1998, 12 (22) :3551-3563
[5]   Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over [J].
Baker, SM ;
Plug, AW ;
Prolla, TA ;
Bronner, CE ;
Harris, AC ;
Yao, X ;
Christie, DM ;
Monell, C ;
Arnheim, N ;
Bradley, A ;
Ashley, T ;
Liskay, RM .
NATURE GENETICS, 1996, 13 (03) :336-342
[6]   Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles [J].
Barlow, C ;
Liyanage, M ;
Moens, PB ;
Deng, CX ;
Ried, T ;
WynshawBoris, A .
NATURE GENETICS, 1997, 17 (04) :462-466
[7]   High copy number suppression of the meiotic arrest caused by a dmc1 mutation:: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway [J].
Bishop, DK ;
Nikolski, Y ;
Oshiro, J ;
Chon, J ;
Shinohara, M ;
Chen, X .
GENES TO CELLS, 1999, 4 (08) :425-443
[8]   RECA HOMOLOGS DMC1 AND RAD51 INTERACT TO FORM MULTIPLE NUCLEAR-COMPLEXES PRIOR TO MEIOTIC CHROMOSOME SYNAPSIS [J].
BISHOP, DK .
CELL, 1994, 79 (06) :1081-1092
[9]   DMC1 - A MEIOSIS-SPECIFIC YEAST HOMOLOG OF ESCHERICHIA-COLI RECA REQUIRED FOR RECOMBINATION, SYNAPTONEMAL COMPLEX-FORMATION, AND CELL-CYCLE PROGRESSION [J].
BISHOP, DK ;
PARK, D ;
XU, LZ ;
KLECKNER, N .
CELL, 1992, 69 (03) :439-456
[10]   PROPERTIES OF SACCHAROMYCES-CEREVISIAE WEE1 AND ITS DIFFERENTIAL REGULATION OF P34(CDC28) IN RESPONSE TO G(1) AND G(2) CYCLINS [J].
BOOHER, RN ;
DESHAIES, RJ ;
KIRSCHNER, MW .
EMBO JOURNAL, 1993, 12 (09) :3417-3426
12345678