PGC-1: The Energetic Regulator in Cardiac Metabolism

被引：117

作者：

Di, Wencheng ^{[1
]}

Lv, Jianjun ^{[2
,3
]}

Jiang, Shuai ^{[4
]}

Lu, Chenxi ^{[2
]}

Yang, Zhi ^{[3
]}

Ma, Zhiqiang ^{[5
]}

Hu, Wei ^{[3
]}

Yang, Yang ^{[2
,3
]}

Xu, Biao ^{[1
]}

机构：

[1] Nanjing Univ, Dept Cardiol, Med Sch, Affiliated Drum Tower Hosp, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China

[2] Northwest Univ, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[4] Fourth Mil Med Univ, Dept Aerosp Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2018年 / 28卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

PROLIFERATOR-ACTIVATED RECEPTOR; ALPHA ERR-ALPHA; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; ATTENUATES MITOCHONDRIAL DYSFUNCTION; NUCLEAR RESPIRATORY FACTOR-1; ACUTE MYOCARDIAL-INFARCTION; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; PROTEIN-KINASE; HEART-FAILURE;

D O I：

10.21775/cimb.028.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1 signaling pathways have also been reported to play a critical role in cardioprotection. Given the significance of PGC-1 coactivators, we summarize the current literature on the molecular mechanisms and roles of PGC-1s in cardiac metabolism. Thus, in this review, we first introduce the basic knowledge regarding PGC-1 signaling pathways. We then discuss their roles in heart metabolism. Moreover, we describe several significant treatments that target the PGC-1 signaling pathway. This review presents the significant roles of PGC-1s in cardiac metabolism and may contribute to the promotion of PGC-1 signaling pathway as a novel therapeutic target.

引用

页码：29 / 46

页数：18

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