Coumarinolignans from the root of Formosan Antidesma pentandrum var. barbatum

被引：17

作者：

Chen, YC

Cheng, MJ

Lee, SJ

Dixit, AK

Ishikawa, T

Tsai, IL

Chen, IS ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Coll Pharm, Kaohsiung 807, Taiwan

[2] Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, Taipei 114, Taiwan

[3] Chiba Univ, Fac Pharmaceut Sci, Chiba 2638522, Japan

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 11期

关键词：

D O I：

10.1002/hlca.200490251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four new coumarinolignans, antidesmanin A (=7-(1,1-dimethylallyl)-2,3-dihydro-3-(4-hydroxy-3,5-dimethoxvphenyl)-10-methoxy-2-methyl-6H-1,4,5-trioxaphenanthren-6-one; 1), antidesmanin B (=3,7-bis(1,1-dimethylallyl)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 2), antidesmanin C (=2,7-bis-(1,1-dimethylallyl)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 3) and antidesmanin D (=2-(3,4-dihydroxyphenyl)-3,7-bis(1,1-dimethylallyl)2,3-dihydroxy-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one or 3-(3,4-dihydroxyphenyl)-2,7-bis(1,1-dimethylallyl)-2,3-dihydro-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 4) have been isolated from the root of the Formosan Antidesma pentandrum var. barbatum. The structures of these new compounds were elucidated by spectroscopic data. Compounds 1-3 exhibited marginal cytotoxicity against MCF-7 (breast) and SF-268 (CNS) cancer cell lines in vitro.

引用

页码：2805 / 2811

页数：7

共 27 条

[1] 5-(3-CARBOXYMETHOXYPHENYL)-2-(4,5-DIMETHYLTHIAZOLYL)-3-(4-SULFOPHENYL)TETRAZOLIUM, INNER SALT (MTS) AND RELATED ANALOGS OF 3-(4,5-DIMETHYLTHIAZOLYL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE (MTT) REDUCING TO PURPLE WATER-SOLUBLE FORMAZANS AS CELL-VIABILITY INDICATORS [J].