Fluorescent bicyclic analogs of cytosine have been synthesized directly from derivatives of 5-iodocytosine by a one-pot sequential Sonogashira cross-coupling and annulation with terminal alkynes. The spectral properties of these compounds depend on the identity of the alkyne. 7-Deazapurines synthesized from substituted phenylacetylenes possess greater fluorescence than those derived from alkyl substituted alkynes.
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NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA
Dash, C
Rausch, JW
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NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA
Rausch, JW
Le Grice, SFJ
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NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA
机构:
NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA
Dash, C
Rausch, JW
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA
Rausch, JW
Le Grice, SFJ
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h-index: 0
机构:
NCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USANCI, Resistance Mech Lab, HIV Drug Resistance Program, Frederick, MD 21702 USA