Malignant transformation of irradiated craniopharyngioma in children Report of 2 cases

被引:28
作者
Aquilina, Kristian [5 ]
Merchant, Thomas E. [3 ]
Rodriguez-Galindo, Carlos [4 ]
Ellison, David W. [2 ]
Sanford, Robert A. [1 ]
Boop, Frederick A. [1 ]
机构
[1] Semmes Murphey Neurol & Spine Inst, Memphis, TN USA
[2] St Jude Childrens Hosp, Dept Pathol, Memphis, TN 38105 USA
[3] St Jude Childrens Hosp, Div Radiat Oncol, Memphis, TN 38105 USA
[4] St Jude Childrens Hosp, Div Solid Tumor Oncol, Memphis, TN 38105 USA
[5] Frenchay Hosp, Dept Neurosurg, Bristol BS16 1LE, Avon, England
关键词
craniopharyngioma; malignant transformation; radiation therapy; GAMMA-KNIFE RADIOSURGERY; RADIATION-THERAPY; PEDIATRIC CRANIOPHARYNGIOMAS; INTRACAVITARY IRRADIATION; RADIOTHERAPY; EXPERIENCE; MANAGEMENT; SURGERY; CHILDHOOD; TUMORS;
D O I
10.3171/2009.9.PEDS09257
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study. (DOI: 10.3171/2009.9.PEDS09257)
引用
收藏
页码:155 / 161
页数:7
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