CROHN'S DISEASE Bacterial clearance in Crohn's disease pathogenesis

被引：7

作者：

Fava, Francesca ^{[1
]}

Danese, Silvio ^{[1
]}

机构：

[1] IRCCS, Ist Clin Humanitas, Div Gastroenterol, IBD Unit, Milan, Italy

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 7卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; ACUTE-INFLAMMATION; AUTOPHAGY; NOD2;

D O I：

10.1038/nrgastro.2010.1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Evidence from a recent study strongly implicates innate immunity in the etiology of Crohn's disease, with particular focus on impaired secretion of cytokines and chemokines by intestinal macrophages in response to bacterial stimuli. These findings highlight the importance of acute inflammatory responses in the first stages of disease pathogenesis.

引用

页码：126 / 128

页数：4

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