CROHN'S DISEASE Bacterial clearance in Crohn's disease pathogenesis

被引：7

作者：

Fava, Francesca ^{[1
]}

Danese, Silvio ^{[1
]}

机构：

[1] IRCCS, Ist Clin Humanitas, Div Gastroenterol, IBD Unit, Milan, Italy

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 7卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; ACUTE-INFLAMMATION; AUTOPHAGY; NOD2;

D O I：

10.1038/nrgastro.2010.1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Evidence from a recent study strongly implicates innate immunity in the etiology of Crohn's disease, with particular focus on impaired secretion of cytokines and chemokines by intestinal macrophages in response to bacterial stimuli. These findings highlight the importance of acute inflammatory responses in the first stages of disease pathogenesis.

引用

页码：126 / 128

页数：4

共 50 条

[21] Genetic Risk Profiling and Prediction of Disease Course in Crohn's Disease Patients
Henckaerts, Liesbet
Van Steen, Kristel
Verstreken, Isabel
Cleynen, Isabelle
Franke, Andre
Schreiber, Stefan
Rutgeerts, Paul
Vermeire, Severine
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2009, 7 (09) : 972 - 980
[22] Dysbiotic microbiota interactions in Crohn's disease
Caparros, Esther
Wiest, Reiner
Scharl, Michael
Rogler, Gerhard
Gutierrez Casbas, Ana
Yilmaz, Bahtiyar
Wawrzyniak, Marcin
Frances, Ruben
GUT MICROBES, 2021, 13 (01)
[23] Digging Out Crohn's Disease Genes
Annese, Vito
INFLAMMATORY BOWEL DISEASES, 2009, 15 (09) : 1436 - 1437
[24] Emerging drugs to treat Crohn's disease
Strauch, Ulrike
Schoelmerich, Juergen
EXPERT OPINION ON EMERGING DRUGS, 2010, 15 (02) : 309 - 322
[25] Distinct and Overlapping Genetic Loci in Crohn's Disease and Ulcerative Colitis: Correlations with Pathogenesis
Waterman, Matti
Xu, Wei
Stempak, Joanne M.
Milgrom, Raquel
Bernstein, Charles N.
Griffiths, Anne M.
Greenberg, Gordon R.
Steinhart, A. Hillary
Silverberg, Mark S.
INFLAMMATORY BOWEL DISEASES, 2011, 17 (09) : 1936 - 1942
[26] The genetics of NOD-like receptors in Crohn's disease
Cummings, J. R. Fraser
Cooney, R. M.
Clarke, G.
Beckly, J.
Geremia, A.
Pathan, S.
Hancock, L.
Guo, C.
Cardon, L. R.
Jewell, D. P.
TISSUE ANTIGENS, 2010, 76 (01): : 48 - 56
[27] The immunopathogenesis of Crohn's disease: a three-stage model
Sewell, Gavin W.
Marks, Daniel J. B.
Segal, Anthony W.
CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (05) : 506 - 513
[28] Etiology of Crohn's disease: many roads lead to autophagy
Lapaquette, Pierre
Brest, Patrick
Hofman, Paul
Darfeuille-Michaud, Arlette
JOURNAL OF MOLECULAR MEDICINE-JMM, 2012, 90 (09): : 987 - 996
[29] Infectious etiopathogenesis of Crohn's disease
Carriere, Jessica
Darfeuille-Michaud, Arlette
Hang Thi Thu Nguyen
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (34) : 12102 - 12117
[30] Interleukin 23 in Crohn's Disease
Eken, Ahmet
Singh, Akhilesh K.
Oukka, Mohamed
INFLAMMATORY BOWEL DISEASES, 2014, 20 (03) : 587 - 595

← 1 2 3 4 5 →