Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0-staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

被引：6

作者：

Boeve, Koos ^{[1
,2
]}

Mastik, Mirjam F. ^{[2
]}

Slagter-Menkema, Lorian ^{[2
,3
]}

van Dijk, Boukje A. C. ^{[4
,5
]}

Roodenburg, Jan L. N. ^{[1
]}

van der Laan, Bernard F. A. M. ^{[3
]}

Witjes, Max J. H. ^{[1
]}

van der Vegt, Bert ^{[2
]}

Schuuring, Ed ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[5] Netherlands Comprehens Canc Org IKNL, Dept Res, Utrecht, Netherlands

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2021年 / 43卷 / 09期

关键词：

lymph node classification; molecular marker; oral cancer; oral squamous cell carcinoma; sentinel lymph node biopsy; SENTINEL NODE BIOPSY; LYMPHATIC DRAINAGE PATTERNS; ELECTIVE NECK DISSECTION; 11Q13; AMPLIFICATION; FADD EXPRESSION; CYCLIN D1; CANCER; OVEREXPRESSION; METASTASIS; PREDICTOR;

D O I：

10.1002/hed.26746

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background In this feasibility study we aimed to evaluate the value of previously reported molecular tumor biomarkers associated with lymph node metastasis in oral squamous cell carcinoma (OSCC) to optimize neck strategy selection criteria. Methods The association between expression of cortactin, cyclin D1, FADD, RAB25, and S100A9 and sentinel lymph node status was evaluated in a series of 87 (cT1-2N0) patients with OSCC treated with primary resection and SLNB procedure. Results Tumor infiltration depth and tumor pattern of invasion were independent prognostic markers for SLN status, while none of the tumor makers showed a better prognostic value to replace SLNB as neck staging technique in the total cohort. However, in the subgroup of patients with pT1N0 OSCC, cortactin expression (OR 16.0, 95%CI 2.0-127.9) was associated with SLN classification. Conclusions Expression of cortactin is a promising immunohistochemical tumor marker to identify patients at low risk that may not benefit from SLNB or END.

引用

页码：2688 / 2697

页数：10