Patient-derived xenograft (PDX) models, applications and challenges in cancer research

被引：181

作者：

Abdolahi, Shahrokh ^{[1
]}

Ghazvinian, Zeinab ^{[2
]}

Muhammadnejad, Samad ^{[3
]}

Saleh, Mahshid ^{[2
]}

Asadzadeh Aghdaei, Hamid ^{[1
]}

Baghaei, Kaveh ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Basic & Mol Epidemiol Gastrointestinal Disorders, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran

[3] Univ Tehran Med Sci, Digest Dis Res Inst, Cell Based Therapies Res Ctr, Tehran, Iran

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2022年 / 20卷 / 01期

关键词：

Cancer animal model; PDX; Preclinical study; Humanized model; Avatar model of cancer; CELL LUNG-CANCER; COMBINED IMMUNODEFICIENCY MICE; IN-VIVO MODELS; TUMOR XENOGRAFTS; MOUSE MODELS; HUMANIZED MICE; MOLECULAR HETEROGENEITY; ANTITUMOR-ACTIVITY; PRECLINICAL MODEL; ESTABLISHMENT;

D O I：

10.1186/s12967-022-03405-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.

引用

页数：15

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