Patient-derived xenograft (PDX) models, applications and challenges in cancer research

被引:153
作者
Abdolahi, Shahrokh [1 ]
Ghazvinian, Zeinab [2 ]
Muhammadnejad, Samad [3 ]
Saleh, Mahshid [2 ]
Asadzadeh Aghdaei, Hamid [1 ]
Baghaei, Kaveh [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Basic & Mol Epidemiol Gastrointestinal Disorders, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran
[3] Univ Tehran Med Sci, Digest Dis Res Inst, Cell Based Therapies Res Ctr, Tehran, Iran
关键词
Cancer animal model; PDX; Preclinical study; Humanized model; Avatar model of cancer; CELL LUNG-CANCER; COMBINED IMMUNODEFICIENCY MICE; IN-VIVO MODELS; TUMOR XENOGRAFTS; MOUSE MODELS; HUMANIZED MICE; MOLECULAR HETEROGENEITY; ANTITUMOR-ACTIVITY; PRECLINICAL MODEL; ESTABLISHMENT;
D O I
10.1186/s12967-022-03405-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
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页数:15
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