Patient-derived xenograft (PDX) models, applications and challenges in cancer research

被引：181

作者：

Abdolahi, Shahrokh ^{[1
]}

Ghazvinian, Zeinab ^{[2
]}

Muhammadnejad, Samad ^{[3
]}

Saleh, Mahshid ^{[2
]}

Asadzadeh Aghdaei, Hamid ^{[1
]}

Baghaei, Kaveh ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Basic & Mol Epidemiol Gastrointestinal Disorders, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran

[3] Univ Tehran Med Sci, Digest Dis Res Inst, Cell Based Therapies Res Ctr, Tehran, Iran

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2022年 / 20卷 / 01期

关键词：

Cancer animal model; PDX; Preclinical study; Humanized model; Avatar model of cancer; CELL LUNG-CANCER; COMBINED IMMUNODEFICIENCY MICE; IN-VIVO MODELS; TUMOR XENOGRAFTS; MOUSE MODELS; HUMANIZED MICE; MOLECULAR HETEROGENEITY; ANTITUMOR-ACTIVITY; PRECLINICAL MODEL; ESTABLISHMENT;

D O I：

10.1186/s12967-022-03405-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.

引用

页数：15

共 147 条

[1] Humanized Mouse Model as a Novel Approach in the Assessment of Human Allogeneic Responses in Organ Transplantation [J].

Ajith, Ashwin ;

Mulloy, Laura L. ;

Abu Musa, Md. ;

Bravo-Egana, Valia ;

Horuzsko, Daniel David ;

Gani, Imran ;

Horuzsko, Anatolij .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[2] An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ [J].

Behbod, Fariba ;

Kittrell, Frances S. ;

LaMarca, Heather ;

Edwards, David ;

Kerbawy, Sofia ;

Heestand, Jessica C. ;

Young, Evelin ;

Mukhopadhyay, Purna ;

Yeh, Hung-Wen ;

Allred, D. Craig ;

Hu, Min ;

Polyak, Kornelia ;

Rosen, Jeffrey M. ;

Medina, Daniel .

BREAST CANCER RESEARCH, 2009, 11 (05)

[3] A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer [J].

Bertotti, Andrea ;

Migliardi, Giorgia ;

Galimi, Francesco ;

Sassi, Francesco ;

Torti, Davide ;

Isella, Claudio ;

Cora, Davide ;

Di Nicolantonio, Federica ;

Buscarino, Michela ;

Petti, Consalvo ;

Ribero, Dario ;

Russolillo, Nadia ;

Muratore, Andrea ;

Massucco, Paolo ;

Pisacane, Alberto ;

Molinaro, Luca ;

Valtorta, Emanuele ;

Sartore-Bianchi, Andrea ;

Risio, Mauro ;

Capussotti, Lorenzo ;

Gambacorta, Marcello ;

Siena, Salvatore ;

Medico, Enzo ;

Sapino, Anna ;

Marsoni, Silvia ;

Comoglio, Paolo M. ;

Bardelli, Alberto ;

Trusolino, Livio .

CANCER DISCOVERY, 2011, 1 (06) :508-523

[4] DEFECTIVE DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS LINKED TO V(D)J RECOMBINATION AND DNA-REPAIR DEFECTS ASSOCIATED WITH THE MURINE SCID MUTATION [J].

BLUNT, T ;

FINNIE, NJ ;

TACCIOLI, GE ;

SMITH, GCM ;

DEMENGEOT, J ;

GOTTLIEB, TM ;

MIZUTA, R ;

VARGHESE, AJ ;

ALT, FW ;

JEGGO, PA ;

JACKSON, SP .

CELL, 1995, 80 (05) :813-823

[5] An ecosystem of cancer cell line factories to support a cancer dependency map [J].

Boehm, Jesse S. ;

Golub, Todd R. .

NATURE REVIEWS GENETICS, 2015, 16 (07) :373-374

[6] Patient-derived xenograft models of colorectal cancer in preclinical research: a systematic review [J].

Brown, Kai M. ;

Xue, Aiqun ;

Mittal, Anubhav ;

Samra, Jaswinder S. ;

Smith, Ross ;

Hugh, Thomas J. .

ONCOTARGET, 2016, 7 (40) :66212-66225

[7] Interrogating open issues in cancer precision medicine with patient-derived xenografts [J].

Byrne, Annette T. ;

Alferez, Denis G. ;

Amant, Frederic ;

Annibali, Daniela ;

Arribas, Joaquin ;

Biankin, Andrew V. ;

Bruna, Alejandra ;

Budinska, Eva ;

Caldas, Carlos ;

Chang, David K. ;

Clarke, Robert B. ;

Clevers, Hans ;

Coukos, George ;

Dangles-Marie, Virginie ;

Eckhardt, S. Gail ;

Gonzalez-Suarez, Eva ;

Hermans, Els ;

Hidalgo, Manuel ;

Jarzabek, Monika A. ;

de Jong, Steven ;

Jonkers, Jos ;

Kemper, Kristel ;

Lanfrancone, Luisa ;

Maelandsmo, Gunhild Mari ;

Marangoni, Elisabetta ;

Marine, Jean-Christophe ;

Medico, Enzo ;

Norum, Jens Henrik ;

Palmer, Hector G. ;

Peeper, Daniel S. ;

Pelicci, Pier Giuseppe ;

Piris-Gimenez, Alejandro ;

Roman-Roman, Sergio ;

Rueda, Oscar M. ;

Seoane, Joan ;

Serra, Violeta ;

Soucek, Laura ;

Vanhecke, Dominique ;

Villanueva, Alberto ;

Vinolo, Emilie ;

Bertotti, Andrea ;

Trusolino, Livio .

NATURE REVIEWS CANCER, 2017, 17 (04) :254-268

[8] Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts [J].

Cassidy, John W. ;

Caldas, Carlos ;

Bruna, Alejandra .

CANCER RESEARCH, 2015, 75 (15) :2963-2968

[9]

Cho SY, 2020, LAB ANIM RES, V36

[10] Colorectal cancer patient-derived xenografted tumors maintain characteristic features of the original tumors [J].

Cho, Yong Beom ;

Hong, Hye Kyung ;

Choi, Yoon-La ;

Oh, Ensel ;

Joo, Kyeung Min ;

Jin, Juyoun ;

Nam, Do-Hyun ;

Ko, Young-Hyeh ;

Lee, Woo Yong .

JOURNAL OF SURGICAL RESEARCH, 2014, 187 (02) :502-509

← 1 2 3 4 5 6 7 8 9 10 →