Metabolic alterations and vulnerabilities in hepatocellular carcinoma

被引：49

作者：

Tenen, Daniel G. ^{[1
,2
]}

Chai, Li ^{[3
]}

Tan, Justin L. ^{[1
,4
,5
]}

机构：

[1] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

[2] Harvard Med Sch, Harvard Stem Cell Inst, Boston, MA 02115 USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] ASTAR, Expt Drug Dev Ctr, 10 Biopolis Rd, Singapore 138670, Singapore

[5] ASTAR, Genome Inst Singapore, Singapore, Singapore

来源：

GASTROENTEROLOGY REPORT | 2021年 / 9卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

hepatocellular carcinoma (HCC); metabolism; metabolic vulnerability; targeted therapy; FATTY LIVER-DISEASE; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; PENTOSE-PHOSPHATE PATHWAY; RAT PYRUVATE-KINASE; O-GLCNACYLATION; STATIN USE; IN-VITRO; NONALCOHOLIC STEATOHEPATITIS; SUCCINATE-DEHYDROGENASE; GLUTAMINE-SYNTHETASE;

D O I：

10.1093/gastro/goaa066

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver cancer is a serious disease. It is ranked as the cancer with the second highest number of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC), which arises from transformed hepatocytes, is the major subtype of liver cancer. It accounts for 85% of total liver-cancer cases. An important aspect of HCC that has been actively studied is its metabolism. With the liver as the primary site of numerous metabolic processes in the body, it has been shown that the metabolism of HCC cells is highly dysregulated compared to that of normal hepatocytes. It is therefore crucial to understand the metabolic alterations caused by HCC and the underlying mechanisms for these alterations. This deeper understanding will allow diagnostic and therapeutic advancements in the treatment of HCC. In this review, we will summarize the current literature in HCC metabolic alterations, induced vulnerabilities, and potential therapeutic interventions.

引用

页码：1 / 13

页数：13

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