Synthesis of Δ3-pyrrolines and Δ3-tetrahydropyridines via microwave-accelerated ring-closing metathesis

被引：38

作者：

Grigg, R ^{[1
]}

Martin, W

Morris, J

Sridharan, V

机构：

[1] Univ Leeds, Sch Chem, Divers & Automated Synth MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] GlaxoSmithKline, Proc Res & Dev, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 26期

关键词：

D O I：

10.1016/s0040-4039(03)01080-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave irradiation effects ring-closing metathesis of electron-deficient and sterically conjested double bonds with a drastic reduction in reaction time and reduced catalyst loading. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4899 / 4901

页数：3

共 14 条

[1]

Armstrong SK, 1998, J CHEM SOC PERK T 1, P371

[2] Comparative investigation of kinetic consequences associated with long-range electronic effects on catalytic ruthenium-promoted ring-closing metathesis [J].

Basu, K ;

Cabral, JA ;

Paquette, LA .

TETRAHEDRON LETTERS, 2002, 43 (31) :5453-5456

[3]

Fürstner A, 2000, ANGEW CHEM INT EDIT, V39, P3012

[4] Ruthenium carbene complexes with N,N′-bis(mesityl) imidazol-2-ylidene ligands:: RCM catalysts of extended scope [J].

Fürstner, A ;

Thiel, OR ;

Ackermann, L ;

Schanz, HJ ;

Nolan, SP .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (07) :2204-2207

[5] Sequential Pd/Ru-catalysed allenylation/olefin metathesis/1,3-dipolar cycloaddition route to novel heterocycles [J].

Grigg, R ;

Hodgson, A ;

Morris, J ;

Sridharan, V .

TETRAHEDRON LETTERS, 2003, 44 (05) :1023-1026

[6] Recent advances in olefin metathesis and its application in organic synthesis [J].

Grubbs, RH ;

Chang, S .

TETRAHEDRON, 1998, 54 (18) :4413-4450

[7] Simple and convenient synthetic procedure leading to ruthenium olefin metathesis catalysts bearing the N,N′-bis(mesityl)imidazol-2-ylidene (IMes) ligand [J].

Jafarpour, L ;

Nolan, SP .

ORGANOMETALLICS, 2000, 19 (11) :2055-2057

[8] Effects of olefin substitution on the ring-closing metathesis of dienes [J].

Kirkland, TA ;

Grubbs, RH .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (21) :7310-7318

[9] Microwave assisted organic synthesis -: a review [J].

Lidström, P ;

Tierney, J ;

Wathey, B ;

Westman, J .

TETRAHEDRON, 2001, 57 (45) :9225-9283

[10] Synthesis of (-)-pinolidoxin: Divergent synthetic strategy exploiting a common silacyclic precursor [J].

Liu, D ;

Kozmin, SA .

ORGANIC LETTERS, 2002, 4 (17) :3005-3007

← 1 2 →