Association of serum leptin levels with central arterial stiffness in coronary artery disease patients

被引:47
作者
Tsai, Jen-Pi [1 ,2 ]
Wang, Ji-Hung [2 ,3 ]
Chen, Mei-Ling [3 ]
Yang, Chiu-Fen [3 ]
Chen, Yu-Chih [3 ]
Hsu, Bang-Gee [2 ,4 ]
机构
[1] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
[2] Tzu Chi Univ, Sch Med, Hualien, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, Taiwan
[4] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien, Taiwan
来源
BMC CARDIOVASCULAR DISORDERS | 2016年 / 16卷
关键词
Arterial stiffness; Carotid-femoral pulse wave velocity; Coronary artery disease; Leptin; PULSE-WAVE VELOCITY; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; DISTENSIBILITY; HYPERTENSION; THERAPY; OBESITY;
D O I
10.1186/s12872-016-0268-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Serum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients. Methods: Fasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and <= 10 m/s as low arterial stiffness. Results: Thirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness. Conclusions: Increasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.
引用
收藏
页数:7
相关论文
共 41 条
  • [1] Relation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index
    Alan, S
    Ulgen, MS
    Ozturk, O
    Alan, B
    Ozdemir, L
    Toprak, N
    [J]. ANGIOLOGY, 2003, 54 (03) : 261 - 267
  • [2] Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
  • [3] 2-S
  • [4] Leptin and atherosclerosis
    Beltowski, Jerzy
    [J]. ATHEROSCLEROSIS, 2006, 189 (01) : 47 - 60
  • [5] Leptin induces oxidative stress in human endothelial cells
    Bouloumié, A
    Marumo, T
    Lafontan, M
    Busse, R
    [J]. FASEB JOURNAL, 1999, 13 (10) : 1231 - 1238
  • [6] Dissociation of Aortic Pulse Wave Velocity With Risk Factors for Cardiovascular Disease Other Than Hypertension A Systematic Review
    Cecelja, Marina
    Chowienczyk, Philip
    [J]. HYPERTENSION, 2009, 54 (06) : 1328 - U103
  • [7] The role of the sympathetic nervous system in obesity-related hypertension
    da Silva, Alexandre A.
    do Carmo, Jussara
    Dubinion, John
    Hall, John E.
    [J]. CURRENT HYPERTENSION REPORTS, 2009, 11 (03) : 206 - 211
  • [8] Hypoadiponectinemia and aldosterone excess are associated with lack of blood pressure control in subjects with resistant hypertension
    de Faria, Ana P. C.
    Demacq, Caroline
    Figueiredo, Valeria N.
    Moraes, Carolina H.
    Santos, Rodrigo C.
    Sabbatini, Andrea R.
    Barbaro, Natalia R.
    Boer-Martins, Leandro
    Fontana, Vanessa
    Moreno, Heitor, Jr.
    [J]. HYPERTENSION RESEARCH, 2013, 36 (12) : 1067 - 1072
  • [9] Atenolol and eprosartan: Differential effects on central blood pressure and aortic pulse wave velocity
    Dhakam, Z
    McEniery, CM
    Yasmin
    Cockcroft, JR
    Brown, MJ
    Wilkinson, IB
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2006, 19 (02) : 214 - 219
  • [10] Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways
    Dhillon, Sandeep S.
    Belsham, Denise D.
    [J]. REGULATORY PEPTIDES, 2011, 167 (2-3) : 192 - 200