Association of serum leptin levels with central arterial stiffness in coronary artery disease patients
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作者:
Tsai, Jen-Pi
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Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Tzu Chi Univ, Sch Med, Hualien, TaiwanBuddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Tsai, Jen-Pi
[1
,2
]
Wang, Ji-Hung
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Tzu Chi Univ, Sch Med, Hualien, Taiwan
Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, TaiwanBuddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Wang, Ji-Hung
[2
,3
]
Chen, Mei-Ling
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Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, TaiwanBuddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Chen, Mei-Ling
[3
]
Yang, Chiu-Fen
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Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, TaiwanBuddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Yang, Chiu-Fen
[3
]
Chen, Yu-Chih
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Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, TaiwanBuddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
Chen, Yu-Chih
[3
]
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机构:
Hsu, Bang-Gee
[2
,4
]
机构:
[1] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Chiayi, Taiwan
[2] Tzu Chi Univ, Sch Med, Hualien, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Div Cardiol, Hualien, Taiwan
[4] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien, Taiwan
Background: Serum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients. Methods: Fasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and <= 10 m/s as low arterial stiffness. Results: Thirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness. Conclusions: Increasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
Cecelja, Marina
Chowienczyk, Philip
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Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England
Cecelja, Marina
Chowienczyk, Philip
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h-index: 0
机构:
Kings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, London British Heart Fdn Ctr, Div Cardiovasc,Dept Clin Pharmacol, London SE1 7EH, England