Potential Hormone Mechanisms of Bariatric Surgery

被引：103

作者：

Dimitriadis, Georgios K. ^{[1
,2
,3
]}

Randeva, Manpal S. ^{[1
]}

Miras, Alexander D. ^{[2
]}

机构：

[1] Univ Warwick, Med Sch, Clin Sci Res Labs, Div Translat & Expt Med, Coventry CV2 2DX, W Midlands, England

[2] Imperial Coll London, Acad Div Diabet Endocrinol & Metab, Hammersmith Campus, London W12 0NN, England

[3] Univ Warwick, Warwick Med Sch, Div Translat & Expt Med Metab & Vasc Hlth, Coventry CV4 7AL, W Midlands, England

来源：

CURRENT OBESITY REPORTS | 2017年 / 6卷 / 03期

关键词：

Bariatric surgery; Gastric banding; Sleeve gastrectomy; Roux-en-Y gastric bypass; Gut hormones; Gastrin; GLP-1; GLP-2; PYY; Ghrelin; CCK; GIP; Oxyntomodulin; Secretin; VIP; PP; Insulin; Glucagon; Somatostatin; Obestatin; Gustducin; FGF19; FGF21; Y GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE-1; LAPAROSCOPIC SLEEVE GASTRECTOMY; BETA-CELL FUNCTION; DUODENAL-JEJUNAL EXCLUSION; INDUCED WEIGHT-LOSS; FOOD-INTAKE; BODY-WEIGHT; GUT HORMONE; OBESE SUBJECTS;

D O I：

10.1007/s13679-017-0276-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized. Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.

引用

页码：253 / 265

页数：13

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