Quality and quantity control at the endoplasmic reticulum

被引：141

作者：

Hegde, Ramanujan S. ^{[1
]}

Ploegh, Hidde L. ^{[2
]}

机构：

[1] NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

[2] Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ANCHORED UBIQUITIN LIGASE; SIGNAL PEPTIDE PEPTIDASE; N-LINKED GLYCANS; MISFOLDED GLYCOPROTEINS; UNCONVENTIONAL SECRETION; DEGRADATION PATHWAY; RETRO-TRANSLOCATION; PROTEIN; COMPLEX; ERAD;

D O I：

10.1016/j.ceb.2010.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome. Cells carefully control the synthetic output of this organelle to regulate both quality and quantity of proteins that emerge. Here, we synthesize current concepts underlying the pathways that mediate protein degradation from the ER and their deployment under physiologic and pathologic conditions.

引用

页码：437 / 446

页数：10

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