High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus-Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis

被引:20
作者
Bouassa, Ralph-Sydney Mboumba [1 ,2 ,5 ]
Belec, Laurent [1 ,2 ]
Gubavu, Camelia [3 ,4 ]
Pere, Helene [1 ,2 ]
Matta, Mathieu [1 ,2 ]
Maka, Artur [3 ,4 ]
Puech, Julien [1 ,2 ]
Wolyec, Serge Tonen [5 ,6 ]
Veyer, David [1 ,2 ]
Gravier, Anne [3 ,4 ]
Hocqueloux, Laurent [3 ,4 ]
Prazuck, Thierry [3 ,4 ]
机构
[1] Hop Europeen Georges Pompidou, AP HP, Lab Virol, 21 Rue Leblanc, F-75015 Paris, France
[2] Univ Paris 05, Paris Sorbonne Cite, 21 Rue Leblanc, F-75015 Paris, France
[3] Ctr Hosp Reg Orleans, Serv Malad Infect & Trop, Orleans, France
[4] Ctr Gratuit Informat Depistage & Diagnost Orleans, Orleans, France
[5] Ecole Doctorale Reg Infectiol Trop, Franceville, Gabon
[6] Univ Kisangani, Fac Med & Pharm, Kisangani, DEM REP CONGO
关键词
Anal and oral HR-HPV; France; HIV preexposure prophylaxis; men who have sex with men; sexual risk behavior; sexually transmitted infections; SEXUALLY-TRANSMITTED INFECTIONS; HIV; HPV; COMPENSATION; PREP; GAY;
D O I
10.1093/ofid/ofz291
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. We assessed the prevalence and risk factors of anal and oral high-risk (HR) human papillomavirus (HPV) infection in human immunodeficiency virus-uninfected men who have sex with men (MSM) and take preexposure prophylaxis (PrEP) in France. Methods. Anal and oral samples were screened by multiplex real-time polymerase chain reaction (Anyplex II HPV 28; Seegene) for HPV DNA. Results. A total of 61 unvaccinated MSM (mean age, 36.1 years) were enrolled. Anal HPV and HR-HPV prevalences were 93.4% and 81.9%, respectively, and oral HPV and HR-HPV prevalences, 33.9% and 19.6%, respectively. HR-HPV type 33 was the most detected genotype, in both anal and oral samples. Among MSM, 68.8% carried 21 anal HPV type targeted by the 9-valent Gardasil-9 vaccine; all oral H PV-positive samples carried >= 1 strain included in the vaccine. Condomless receptive anal intercourse and history of anal gonorrhea were the main factors associated with increased risk for anal HPV infection (adjusted odds ratio, 10.4) and anal infection with multiple HR-HPV genotypes (5.77), respectively. Conversely, having had <10 partners in the last 12 months was associated with decreased risk for anal carriage of both multiple HPV (adjusted odds ratio, 0.19) and HR-HPV (0.17) types. Conclusion. French MSM using PrEP are at high risk for both anal and oral carriage of HR-HPV that could lead to HPV-related cancers.
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页数:9
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