Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome

被引：191

作者：

McCabe, Laura ^{[1
,2
]}

Britton, Robert A. ^{[3
]}

Parameswaran, Narayanan ^{[1
]}

机构：

[1] Michigan State Univ, Dept Physiol, Biomed Imaging Res Ctr, Biomed Phys Sci Bldg,567 Wilson Rd, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Radiol, Biomed Imaging Res Ctr, E Lansing, MI 48824 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Alkek Ctr Metagen & Microbiome Res, Houston, TX 77030 USA

来源：

CURRENT OSTEOPOROSIS REPORTS | 2015年 / 13卷 / 06期

关键词：

Bone density; Prebiotics; Probiotics; Microbiome; Osteoblast; Osteoclast; DIFRUCTOSE-ANHYDRIDE-III; INULIN-TYPE FRUCTANS; INCREASE CALCIUM-ABSORPTION; HELVETICUS-FERMENTED MILK; MINERAL DENSITY; DIETARY FRUCTOOLIGOSACCHARIDES; FEMORAL BONE; NONDIGESTIBLE OLIGOSACCHARIDES; OSTEOCLAST DIFFERENTIATION; ESTROGEN DEFICIENCY;

D O I：

10.1007/s11914-015-0292-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in our understanding of how the intestinal microbiome contributes to health and disease have generated great interest in developing strategies for modulating the abundance of microbes and/or their activity to improve overall human health and prevent pathologies such as osteoporosis. Bone is an organ that the gut has long been known to regulate through absorption of calcium, the key bone mineral. However, it is clear that modulation of the gut and its microbiome can affect bone density and strength in a variety of animal models ( zebrafish, rodents, chicken) and humans. This is demonstrated in studies ablating the microbiome through antibiotic treatment or using germ-free mouse conditions as well as in studies modulating the microbiome activity and composition through prebiotic and/or probiotic treatment. This review will discuss recent developments in this new and exciting area.

引用

页码：363 / 371

页数：9

共 75 条

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