Daratumumab (Anti-CD38) for Treatment of Disseminated Nontuberculous Mycobacteria in a Patient With Anti-Interferon-γ Autoantibodies

被引：30

作者：

Ochoa, Sebastian ^{[1
]}

Ding, Li ^{[1
]}

Kreuzburg, Samantha ^{[1
]}

Treat, Jennifer ^{[2
]}

Holland, Steven M. ^{[1
]}

Zerbe, Christa S. ^{[1
]}

机构：

[1] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA

[2] Med Sci & Comp, Rockville, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 12期

基金：

美国国家卫生研究院;

关键词：

daratumumab; mycobacteria; disseminated; interferon gamma; autoantibodies;

D O I：

10.1093/cid/ciaa1086

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with autoantibodies to interferon-gamma (IFN-gamma) may develop severe nontuberculous mycobacterial infections. We describe the novel use of daratumumab in a patient with autoantibodies to IFN-gamma who had progressive infection, resulting in clinical and radiographic improvement.

引用

页码：2206 / 2208

页数：3

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