The relationship between virus load response to highly active antiretroviral therapy and change in CD4 cell counts: A report from the women's interagency HIV study

被引：16
作者：
DeHovitz, JA
Kovacs, A
Feldman, JG
Anastos, K
Young, M
Cohen, M
Gange, SJ
Melnick, S
Greenblatt, RM
机构：
[1] Suny Downstate Med Ctr, Dept Prevent Med & Community Hlth, Brooklyn, NY 11201 USA
[2] Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11201 USA
[3] Catholic Med Ctr New York, Dept Med, New York, NY USA
[4] Univ So Calif, Div Pediat Infect Dis, Los Angeles, CA USA
[5] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[6] Georgetown Univ, Dept Med, Washington, DC USA
[7] Cook Cty Hosp, Dept Med, Chicago, IL 60612 USA
[8] Johns Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[9] NCI, Analyt Epidemiol Res Branch, Bethesda, MD 20892 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2000年 / 182卷 / 05期
关键词：
D O I：
10.1086/315875
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The relationship between the pattern of virus load response to highly active antiretroviral therapy (HAART) and CD4 lymphocyte response was assessed in a cohort of 249 human immunodeficiency virus (HIV) type 1-infected women at 3 times: 1 before and 2 after initiation of therapy, with follow-up of 6-12 months. Patients with a durable response to HAART (i.e >1 log decrease in HIV-1 RNA sustained for the study periods) had a continuous and significant increase in CD4 cell counts over time, whereas those with no response (<0.5 log decrease in HIV-1 RNA) had a sight decline. Patients with a mixed response (initial decrease >1 log, followed by a subsequent decrease <0.5 log) had an increase in CD4 cell count, followed by a plateau. The trend in CD4 cell count differed significantly by response to HAART, with those patients who experienced a durable response having significantly higher CD4 cell counts than others.
引用
收藏
页码：1527 / 1530
页数：4
相关论文
共 15 条
[1]   The Women's Interagency HIV Study [J].
Barkan, SE ;
Melnick, SL ;
Preston-Martin, S ;
Weber, K ;
Kalish, LA ;
Miotti, P ;
Young, M ;
Greenblatt, R ;
Sacks, H ;
Feldman, J .
EPIDEMIOLOGY, 1998, 9 (02) :117-125
[2]   Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection [J].
Deeks, SG ;
Barbour, JD ;
Martin, JN ;
Swanson, MS ;
Grant, RM .
JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) :946-953
[3]   HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: Response to both initial and salvage therapy [J].
Deeks, SG ;
Hecht, FM ;
Swanson, M ;
Elbeik, T ;
Loftus, R ;
Cohen, PT ;
Grant, RM .
AIDS, 1999, 13 (06) :F35-F43
[4]  
*DEP HHS, 1999, GUID US ANT AG HIV I
[5]  
GANGE SJ, 1999, NAT C WOM HIV AIDS L, P35
[6]   Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy [J].
Gulick, RM ;
Mellors, JW ;
Havlir, D ;
Eron, JJ ;
Gonzalez, C ;
McMahon, D ;
Richman, DD ;
Valentine, FT ;
Jonas, L ;
Meibohm, A ;
Emini, EA ;
Chodakewitz, JA .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (11) :734-739
[7]   Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection - 100-week follow-up [J].
Gulick, RM ;
Mellors, JW ;
Havlir, D ;
Eron, JJ ;
Gonzalez, C ;
McMahon, D ;
Jonas, L ;
Meibohm, A ;
Holder, D ;
Schleif, WA ;
Condra, JH ;
Emini, EA ;
Isaacs, R ;
Chodakewitz, JA ;
Richman, DD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (01) :35-41
[8]   CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART) [J].
Kaufmann, D ;
Pantaleo, G ;
Sudre, P ;
Telenti, A .
LANCET, 1998, 351 (9104) :723-724
[9]   Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study [J].
Ledergerber, B ;
Egger, M ;
Opravil, M ;
Telenti, A ;
Hirschel, B ;
Battegay, M ;
Vernazza, P ;
Sudre, P ;
Flepp, M ;
Furrer, H ;
Francioli, P ;
Weber, R .
LANCET, 1999, 353 (9156) :863-868
[10]   Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions [J].
Lucas, GM ;
Chaisson, RE ;
Moore, RD .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (02) :81-+
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