Cocaine is one of the most commonly used substances of abuse The use of beta-blockers in cocaine Induced acute coronary syndrome has long been a matter of debate While it is widely believed that beta-blockers are contraindicated in cocaine toxicity, there appears to be some recognizable role fat certain beta-blockers in ameliorating the cardiovascular as well as central nervous system effects of cocaine This article explores the role of beta-blockers in the management of cocaine toxicity Published by Elsevier B V on behalf of European Federation of Internal Medicine