Sub-chronic arsenic exposure aggravates nephrotoxicity in experimental diabetic rats

被引：0
作者：
Patel, Hitesh Vashrambhai [1 ]
Kalia, Kiran [1 ]
机构：
[1] Sardar Patel Univ, Biochem Lab, BRD Sch Biosci, Vallabh Vidyanagar 388120, Gujarat, India
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2010年 / 48卷 / 07期
关键词：
Arsenic; Diabetes mellitus; Oxidative stress; Renal tissue; OXIDATION PROTEIN PRODUCTS; KIDNEY-DISEASE; STRESS; LIVER; ASSAY; GLUTATHIONE; MORTALITY; TISSUES;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The present experiment was planned to study nephrotoxicity in experimental diabetic rats under sub-chronic exposure to arsenic. Alloxan induced diabetic and control rats were exposed to sodium arsenite (0 and 5.5 mg/kg, orally) for 30 days. More pronounced nephrotoxic effects were noted in arsenic exposed diabetic group as evidenced by increased blood urea nitrogen, serum creatinine and relative kidney weight and decreased level of reduced glutathione and glutathione peroxidase activity compared to non arsenic exposed diabetic group. Increased level of lipid peroxidation, protein oxidation, superoxide dismutase and catalase activities under diabetic condition remained unchanged in arsenic exposed diabetic group compared to unexposed diabetic group.
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页码：762 / 768
页数：7
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