A Leukemic Presentation of Alveolar Rhabdomyosarcoma in a 52-Year-Old Woman Without an Identifiable Primary Tumor

被引：7

作者：

Kern, Jason B. ^{[1
]}

Hii, Anselm ^{[2
]}

Kruse, Matthew J. ^{[1
]}

Szabo, Zsolt ^{[1
]}

Argani, Pedram ^{[1
]}

Hibbard, Michele K. ^{[2
]}

Gladstone, Douglas E. ^{[1
]}

Meyer, Christian ^{[1
]}

Zheng, Rui ^{[1
]}

Borowitz, Michael J. ^{[1
]}

Duffield, Amy S. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21231 USA

[2] Clarient Inc, Aliso Viejo, CA USA

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2015年 / 23卷 / 01期

关键词：

alveolar rhabdomyosarcoma; bone marrow; immunohistochemistry; flow cytometry; cytogenetics; BONE-MARROW; EXPRESSION; PATIENT; BIOPSY;

D O I：

10.1177/1066896914553666

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.

引用

页码：75 / 77

页数：3

共 14 条

[1] Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall [J].

Bahrami, Armita ;

Gown, Allen M. ;

Baird, Geoffrey S. ;

Hicks, M. John ;

Folpe, Andrew L. .

MODERN PATHOLOGY, 2008, 21 (07) :795-806

[2] Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: A study of 135 cases [J].

Cessna, MH ;

Zhou, H ;

Sanger, WG ;

Perkins, SL ;

Tripp, S ;

Pickering, D ;

Daines, C ;

Coffin, CM .

MODERN PATHOLOGY, 2002, 15 (09) :931-938

[3] CD56 expression of neuroendocrine neoplasms on immunophenotyping by flow cytometry - A novel diagnostic approach to fine-needle aspiration biopsy [J].

Farinola, MA ;

Weir, EG ;

Ali, SZ .

CANCER CYTOPATHOLOGY, 2003, 99 (04) :240-246

[4] Cervical epidural rhabdomyosarcoma with a leukemia-like presentation in an aged patient - Case report [J].

Haisa, T ;

Kondo, T ;

Miwa, A ;

Saitoh, K .

NEUROLOGIA MEDICO-CHIRURGICA, 1999, 39 (03) :234-237

[5]

Kahn DG, 1998, ARCH PATHOL LAB MED, V122, P375

[6]

Khanna R, 2012, INTERNET J ONCOL, V8

[7]

Parham D.M., 2013, WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone, V4th, P127

[8] Classification of Rhabdomyosarcoma and Its Molecular Basis [J].

Parham, David M. ;

Barr, Frederic G. .

ADVANCES IN ANATOMIC PATHOLOGY, 2013, 20 (06) :387-397

[9] ALVEOLAR RHABDOMYOSARCOMA INFILTRATING BONE-MARROW AT PRESENTATION - THE VALUE TO DIAGNOSIS OF BONE-MARROW TREPHINE BIOPSY SPECIMENS [J].

REID, MM ;

SAUNDERS, PWG ;

BOWN, N ;

BRADFORD, CR ;

MAUNG, ZT ;

CRAFT, AW ;

MALCOLM, AJ .

JOURNAL OF CLINICAL PATHOLOGY, 1992, 45 (09) :759-762

[10]

Reinecke P, 1998, PROCEEDINGS OF THE GERMAN SOCIETY FOR PATHOLOGY 82ND MEETING - 1998, P336

← 1 2 →