Standards and standardization in mastocytosis:: Consensus statements on diagnostics, treatment recommendations and response criteria

被引：596

作者：

Valent, P.

Akin, C.

Escribano, L.

Foedinger, M.

Hartmann, K.

Brockow, K.

Castells, M.

Sperr, W. R.

Kluin-Nelemans, H. C.

Hamdy, N. A. T.

Lortholary, O.

Robyn, J.

van Doormaal, J.

Sotlar, K.

Hauswirth, A. W.

Arock, M.

Hermine, O.

Hellmann, A.

Triggiani, M.

Niedoszytko, M.

Schwartz, L. B.

Orfao, A.

Horny, H.-P.

Metcalfe, D. D.

机构：

[1] Med Univ Vienna, Div Haematol & Haemostaseol, Dept Internal Med 1, A-1090 Vienna, Austria

[2] Univ Michigan, Div Allergy & Immunol, Dept Internal Med, Ann Arbor, MI 48109 USA

[3] Hosp Ramon & Cajal, Unidad Mastocitosis, Hematol Serv, E-28034 Madrid, Spain

[4] Med Univ Vienna, Clin Inst Med & Chem Lab Diagnost, Vienna, Austria

[5] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, D-8000 Munich, Germany

[6] Univ Cologne, Clin Dermatol & Venerol, D-5000 Cologne 41, Germany

[7] Univ Cologne, Polyclin Dermatol & Venerol, D-5000 Cologne 41, Germany

[8] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[9] Univ Groningen, Ctr Med, Dept Haematol, NL-9700 AB Groningen, Netherlands

[10] Leiden Univ, Ctr Med, Dept Endocrinol & Metab Dis, NL-2300 RA Leiden, Netherlands

[11] Univ Paris 05, Hop Necker Enfants Malades, Serv Maladies Infect, F-75270 Paris 06, France

[12] NHLBI, Haematol Branch, NIH, Bethesda, MD 20892 USA

[13] Univ Tubingen, Inst Pathol, D-72074 Tubingen, Germany

[14] Univ Hosp Groningen, Dept Allergol, Groningen, Netherlands

[15] Ecole Normale Super, CNRS, UMR 8113, LBPA, Cachan, France

[16] Univ Paris 05, Assistance Publ Hop Paris, Hop Necker Paris, Dept Adult Haematol, F-75005 Paris, France

[17] Univ Paris 05, Assistance Publ Hop Paris, Hop Necker Paris, CNRS,UMR 8147, F-75005 Paris, France

[18] Med Univ Gdansk, Dept Haematol, Gdansk, Poland

[19] Univ Naples Federico II, Fac Med & Chirurg, Cattedra Immunol Clin & Allergol, Naples, Italy

[20] Med Univ Gdansk, Dept Allergol, Gdansk, Poland

[21] Virginia Commonwealth Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA 23284 USA

[22] Univ Salamanca, Serv Cent Citometria, Ctr Invest Canc, E-37008 Salamanca, Spain

[23] Univ Salamanca, Dept Med, E-37008 Salamanca, Spain

[24] Univ Schleswig Holstein, Inst Pathol, Lubeck, Germany

[25] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 37卷 / 06期

关键词：

criteria; mastocytosis; patient selection; standardization; targeted drugs;

D O I：

10.1111/j.1365-2362.2007.01807.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses. To address these demands, leading experts discussed current issues and standards in mastocytosis in a Working Conference. The present article provides the resulting outcome with consensus statements, which focus on the appropriate application of clinical and laboratory tests, patient selection for interventional therapy, and the selection of appropriate drugs. In addition, treatment response criteria for the various clinical conditions, disease-specific symptoms, and specific pathologies are provided. Resulting recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.

引用

页码：435 / 453

页数：19

共 136 条

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