In Vitro Activity of Eravacycline in Combination with Colistin Against OXA-type Carbapenemase Producing Klebsiella pneumoniae Isolates

被引：2
|
作者：
Ozger, H. Selcuk [1 ]
Cuhadar, Tugba [2 ]
Yildiz, Serap Suzuk [3 ,4 ]
Gulmez, Zehra Demirbas [1 ]
Tunccan, Ozlem Guzel [1 ]
Kalkanci, Ayse [2 ]
Simsek, Husniye [3 ]
Bakkaloglu, Zekiye [4 ]
Dizbay, Murat [1 ]
机构：
[1] Gazi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, TR-06560 Ankara, Turkey
[2] Gazi Univ, Dept Clin Microbiol, Sch Med, Ankara, Turkey
[3] Minist Hlth, Gen Directorate Publ Hlth, Natl AMR Surveillance Lab, Ankara, Turkey
[4] Minist Gen Directorate Publ Hlth, Cent Lab, Ankara, Turkey
来源：
GAZI MEDICAL JOURNAL | 2021年 / 32卷 / 2A期
关键词：
Eravacycline; Colistin; Synergy; Klebsiella pneumoniae; Time-kill assay; RESISTANT ENTEROBACTERIACEAE; ACINETOBACTER-BAUMANNII; SYNERGY; FLUOROCYCLINE; SURVEILLANCE; TIGECYCLINE; EFFICACY; GENES; VIVO;
D O I：
10.12996/gmj.2021.64
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: The synergistic activity of eravacycline in combination with colistin on Oxacillinase (OXA) producing carbapenem-resistant Klebsiella pneumoniae isolates (CR-Kp) was evaluated in this study. Methods: Minimum inhibitory concentrations of meropenem were determined by the broth microdilution method. All strains screened for carbapenemase activity by PCR. Chequerboard assay and time-kill analysis were used to assess potential synergy. Results: Synergistic activity was found in 40 % of the strains by chequerboard assay. No antagonism was detected. Comparing to colistin alone at subinhibitory concentrations synergistic and bactericidal activity was observed when it combined with eravacycline. A Similar activity was also observed in colistinresistant CR- Kp isolates. Conclusion: Our results indicate that Eravacycline and colistin combination may be a potential therapeutic option for the treatment of CR- Kp infections.
引用
收藏
页码：276 / 280
页数：5
相关论文
共 50 条
  • [1] Multidrug-resistant Klebsiella pneumoniae clinical isolates producing NDM- and OXA-type carbapenemase in Nepal
    Takei, Satomi
    Tabe, Yoko
    Miida, Takashi
    Hishinuma, Tomomi
    Khasawneh, Abdullah
    Kirikae, Teruo
    Sherchand, Jeevan B.
    Tada, Tatsuya
    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2024, 37 : 233 - 243
  • [2] In vitro activity of eravacycline in combination with colistin against carbapenem-resistant A. baumannii isolates
    Ozger, H. Selcuk
    Cuhadar, Tugba
    Yildiz, Serap Suzuk
    Gulmez, Zehra Demirbas
    Dizbay, Murat
    Tunccan, Ozlem Guzel
    Kalkanci, Ayse
    Simsek, Husniye
    Unaldi, Ozlem
    JOURNAL OF ANTIBIOTICS, 2019, 72 (08) : 600 - 604
  • [3] Evaluation of in vitro methods for testing tigecycline combinations against carbapenemase-producing Klebsiella pneumoniae isolates
    Papoutsaki, Vassiliki
    Galani, Irene
    Papadimitriou, Eleni
    Karantani, Irene
    Karaiskos, Ilias
    Giamarellou, Helen
    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 20 : 98 - 104
  • [4] Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae
    Pachon-Ibanez, Maria E.
    Labrador-Herrera, Gema
    Cebrero-Cangueiro, Tania
    Diaz, Caridad
    Smani, Younes
    del Palacio, Jose P.
    Rodriguez-Bano, Jesus
    Pascual, Alvaro
    Pachon, Jeronimo
    Carmen Conejo, M.
    FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [5] In vitro synergistic activity of fosfomycin in combination with meropenem, amikacin and colistin against OXA-48 and/or NDM-producing Klebsiella pneumoniae
    Sengel, Buket Erturk
    Gelmez, Gulsen Altinkanat
    Soyletir, Guner
    Korten, Volkan
    JOURNAL OF CHEMOTHERAPY, 2020, 32 (05) : 237 - 243
  • [6] The Effects of Colistin on Imipenem MICs in OXA-48 Producing Klebsiella pneumoniae Isolates: An In Vitro Study
    Duman, Yucel
    Tekerekoglu, Mehmet Sait
    Kuzucu, Cigdem
    Yakupogullari, Yusuf
    MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, 2021, 10
  • [7] In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPC-producing Klebsiella pneumoniae bloodstream isolates
    Gaibani, Paolo
    Lombardo, Donatella
    Lewis, Russell E.
    Mercuri, Marcella
    Bonora, Sonia
    Landini, Maria Paola
    Ambretti, Simone
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (07) : 1856 - 1865
  • [8] In Vitro Synergism of Azithromycin Combination with Antibiotics against OXA-48-Producing Klebsiella pneumoniae Clinical Isolates
    Singkham-in, Uthaibhorn
    Muhummudaree, Netchanok
    Chatsuwan, Tanittha
    ANTIBIOTICS-BASEL, 2021, 10 (12):
  • [9] In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48-positive Klebsiella pneumoniae strains
    Evren, Ebru
    Azap, Ozlem Kurt
    Colakoglu, Sule
    Arslan, Hande
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2013, 76 (03) : 335 - 338
  • [10] Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K-pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin
    Tang, Hung-Jen
    Lai, Chih-Cheng
    Chen, Chi-Chung
    Zhang, Chun-Cheng
    Weng, Tzu-Chieh
    Chiu, Yu-Hsin
    Toh, Han-Siong
    Chiang, Shyh-Ren
    Yu, Wen-Liang
    Ko, Wen-Chien
    Chuang, Yin-Ching
    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2019, 52 (02) : 273 - 281
12345