Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis

被引：50

作者：

Karampitsakos, Theodoros ^{[1
]}

Torrisi, Sebastiano ^{[2
,12
]}

Antoniou, Katerina ^{[3
]}

Manali, Effrosyni ^{[4
]}

Korbila, Ioanna ^{[4
]}

Papaioannou, Ourania ^{[1
]}

Sampsonas, Fotios ^{[1
]}

Katsaras, Matthaios ^{[1
]}

Vasarmidi, Eirini ^{[3
]}

Papakosta, Despoina ^{[5
]}

Domvri, Kalliopi ^{[5
]}

Fouka, Eva ^{[5
]}

Organtzis, Ioannis ^{[5
]}

Daniil, Zoe ^{[6
]}

Dimeas, Ilias ^{[6
]}

Kirgou, Paraskevi ^{[6
]}

Gourgoulianis, Konstantinos I. ^{[6
]}

Papanikolaou, Ilias C. ^{[7
]}

Markopoulou, Katerina ^{[8
]}

Kounti, Georgia ^{[8
]}

Tsapakidou, Eirini ^{[8
]}

Papadopoulou, Efthymia ^{[8
]}

Tatsis, Konstantinos ^{[9
]}

Gogali, Athena ^{[9
]}

Kostikas, Konstantinos ^{[9
]}

Tzilas, Vasilios ^{[10
]}

Chrysikos, Serafeim ^{[11
]}

Papiris, Spyridon ^{[4
]}

Bouros, Demosthenes ^{[10
]}

Kreuter, Michael ^{[2
,12
]}

Tzouvelekis, Argyrios ^{[1
,10
]}

机构：

[1] Univ Hosp Patras, Dept Resp Med, Patras, Greece

[2] Heidelberg Univ, Ctr Interstitial & Rare Lung Dis, Pneumol, Thoraxk Linik, Heidelberg, Germany

[3] Univ Crete, Dept Resp Med, Lab Mol & Cellular Pneumonol, Fac Med, Iraklion, Crete, Greece

[4] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Athens Med Sch, Pulm Med Dept 2, Athens, Greece

[5] Aristotle Univ Thessaloniki, Med Sch, G PAPANIKOLAOU Gen Hosp, Pulm Dept, Thessaloniki, Greece

[6] Univ Thessaly, Sch Med, Dept Resp Med, Larisa, Greece

[7] Corfu Gen Hosp, Dept Resp Med, Corfu, Greece

[8] G PAPANIKOLAOU Gen Hosp, Pulm Dept, Thessaloniki, Greece

[9] Univ Ioannina, Sch Med, Dept Resp Med, Ioannina, Greece

[10] Natl & Kapodistrian Univ Athens, Acad Dept Pneumonol 1, Med Sch, Hosp Thorac Dis,SOTIRIA, Athens, Greece

[11] Hosp Thorac Dis, Dept Pneumol 5, SOTIRIA, Athens, Greece

[12] German Ctr Lung Res, Heidelberg, Germany

来源：

RESPIRATORY RESEARCH | 2021年 / 22卷 / 01期

关键词：

Monocyte count; RDW; Idiopathic pulmonary fibrosis; Biomarkers; Mortality; ACUTE EXACERBATION; PERIPHERAL-BLOOD; CLINICAL-COURSE; PIRFENIDONE; MULTICENTER; SURVIVAL; CAPACITY; PROFILE; PREDICTION; VALIDATION;

D O I：

10.1186/s12931-021-01725-9

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naive patients with IPF were retrospectively enrolled from two independent cohorts (derivation and validation) and split into subgroups (high and low) based on median baseline monocyte count and red cell distribution width (RDW). Results Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed. In the derivation cohort, patients with monocyte count >= 0.60 K/mu L had significantly lower median FVC%pred [75.0, (95% CI 71.3-76.7) vs. 80.9, (95% CI 77.5-83.1), (P = 0.01)] and DLCO%pred [47.5, (95% CI 44.3-52.3) vs. 53.0, (95% CI 48.0-56.7), (P = 0.02)] than patients with monocyte count < 0.60 K/mu L. Patients with RDW >= 14.1% had significantly lower median FVC%pred [75.5, (95% CI 71.2-79.2) vs. 78.3, (95% CI 76.0-81.0), (P = 0.04)] and DLCO%pred [45.4, (95% CI 43.3-50.5) vs. 53.0, (95% CI 50.8-56.8), (P = 0.008)] than patients with RDW < 14.1%. Cut-off thresholds from the derivation cohort were applied to the validation cohort with similar discriminatory value, as indicated by significant differences in median DLCO%pred between patients with high vs. low monocyte count [37.8, (95% CI 35.5-41.1) vs. 45.5, (95% CI 41.9-49.4), (P < 0.001)] and RDW [37.9, (95% CI 33.4-40.7) vs. 44.4, (95% CI 41.5-48.9), (P < 0.001)]. Patients with high monocyte count and RDW of the validation cohort exhibited a trend towards lower median FVC%pred (P = 0.09) and significantly lower median FVC%pred (P = 0.001), respectively. Kaplan-Meier analysis in the derivation cohort demonstrated higher all-cause mortality in patients with high (>= 0.60 K/mu L) vs. low monocyte count (< 0.60 K/mu L) [HR 2.05, (95% CI 1.19-3.53), (P = 0.01)]. Conclusions Increased monocyte count and RDW may represent negative prognostic biomarkers in patients with IPF.

引用

页数：10

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