The effect of symptom clusters on functional status and quality of life in women with breast cancer

被引:214
作者
Dodd, Marylin J. [1 ]
Cho, Maria H. [1 ]
Cooper, Bruce A. [2 ]
Miaskowski, Christine [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol Nursing, Sch Nursing, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Community Hlth Syst, Sch Nursing, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
Symptom experience; Symptom cluster; Pain; Fatigue; Sleep disturbance; Depression; Cluster analysis; Functional status; Quality of life; ADJUVANT CHEMOTHERAPY; FATIGUE; IMPACT; SLEEP; PAIN; DEPRESSION; VERSION; INTERFERENCE; VALIDATION; EXPERIENCE;
D O I
10.1016/j.ejon.2009.09.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The purposes of this study of women with breast cancer receiving chemotherapy with/without radiation therapy were to determine whether: (1) subgroups of oncology outpatients can be identified based on a specific symptom cluster (i.e., pain, fatigue, sleep disturbances, depression); (2) these subgroups differ on outcomes (i.e., functional status, quality of life); (3) subgroup membership changes over time. Methods: A secondary data analysis using data collected from 112 women at initial chemotherapy. Symptom and outcome measures were completed at three time points: baseline (i.e., the week before cycle two - T1); end of cancer treatment (T2), end of the study (approximately one year after the start of chemotherapy - 13). Cluster analysis identified patient subgroups based on symptom severity scores. Results: At T1 and T2, four patient subgroups were identified: ALL LOW (one or no symptom greater than the cut score), MILD (two symptoms), MODERATE (three or four symptoms), and ALL HIGH (four symptoms). At T3, three subgroups were identified: MILD, MODERATE and ALL HIGH. Subgroups with high severity levels of all four symptoms had poorer functional status and QOL at each time point than other subgroups (p < 0.001). Group membership changed over time. Conclusions: Subgroups of patients with different symptom experiences were identified. For some patients severity of all four symptoms persisted months after cancer treatment. Initial and ongoing assessment to identify those patients in the ALL HIGH patient subgroup is important so that appropriate interventions to improve functional status and quality of life can be offered. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:101 / 110
页数:10
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