A simplified three-times weekly daptomycin dosing regimen for chronic hemodialysis patients

被引：1

作者：

Burkhardt, Olaf ^{[2
]}

Kielstein, Jan T. ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Hypertens & Nephrol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Dept Pulm Med, D-30625 Hannover, Germany

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2010年 / 8卷 / 01期

关键词：

daptomycin; dialysis; end-stage renal disease; infection; pharmacokinetics; STAGE RENAL-DISEASE; PHARMACOKINETICS; MORTALITY; KIDNEY;

D O I：

10.1586/ERI.09.121

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Approximately 2.3 million patients worldwide are undergoing chronic renal replacement therapy. In that population, acute infections substantially contribute to the excessive morbidity and mortality. The risk for invasive methicillin-resistant Staphylococcus aureus infections in this population is approximately 100-fold higher than in the general population, therefore dialysis patients currently account for up to approximately 15% of all invasive methicillin-resistant Staphylococcus aureus infections. A simplified three-times weekly dosing regimen for hemodialysis patients now allows for practical, hassle-free and effective treatment with claptomycin, which is licensed for the treatment of complicated skin and soft tissue infections, including resistant strains of Staphylococcus aureus and life-threatening Gram-positive infections, vancomycin-resistant enterococcal infections and right-sided endocarditis.

引用

页码：11 / 14

页数：4

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