Synthesis, characterization and drug delivery behaviors of new PCP polymeric micelles

被引:19
|
作者
Liu, Der-Zen
Hsieh, Jui-Hsiang
Fan, Xian-Chan
Yang, Jean-Dean
Chung, Tze-Wen [1 ]
机构
[1] Natl Yunlin Univ Sci & Technol, Dept Chem Engn, Yunlin 640, Taiwan
[2] Taipei Med Univ, Grad Inst Biomed Mat, Taipei, Taiwan
[3] Chung Yuan Christian Univ, Dept Biomed Engn, Chungli 320, Taiwan
[4] ITRI, Inst Biomed Engn, Hsinchu 310, Taiwan
关键词
chitooligosaccharide (COS); poly(epsilon-caprolactone); polymeric micelles; genipin; drug delivery;
D O I
10.1016/j.carbpol.2006.10.019
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A new PCP tri-block copolymer consisting of poly (epsilon:-caprolactone)-b-chitooligosaccharide-b-poly(ethylene glycol) (PCL-b-COS-bPEG, PCP) was synthesized and characterized. The potential for delivering doxorubicin (DOX), a model drug, with or without genipin crosslinking was evaluated. The PCP copolymers were analyzed by Fourier-transform infrared spectrometry (FT-IR) to confirm the amine and ester groups of the COS and the PCL of the copolymer, respectively. H-1 nuclear magnetic resonance (1H NMR) was performed to determine the structure of the PCP copolymer for demonstrating both PCL and PEG blocks grafted onto the COS block. Moreover, gel permeation chromatography (GPC) was applied to determine the number average molecular weight of the tri-block copolymer (M,,), which was 11,340 Da/mole. The PCP form polymeric micelles at the critical micelle concentration (CMC) of 0.0107 wt% (or 1.0 mu M) with the mean diameter 90 nm, as determined by a dynamic light-scattering (DLS) analyzer. Since PCP micelles contain COS, the zeta potentials of the micelles are changed from a neutral (e.g., -3.2 +/- 1.3 mV at pH 7.4) to a cationic state (13.9 +/- 4.4 mV at pH 3.0) when pH values of the suspension medium are varied. This change is a unique property of the micelles. In addition, drug delivery behavior of the PCP micelles is influenced by genipin crosslinking COS. The DOX release period of crosslinked micelles is significantly longer than that of the non-crosslinked ones (e.g., 8 days vs. 4 days, respectively) while the burst release of DOX of crosslinked ones is significantly reduced compared with that of non-crosslinked ones. In conclusion, a new tri-block COS-containing PCP copolymer/polymeric micelle has been synthesized and characterized, Moreover, the unique properties of COS-containing PCP micelles are demonstrated by varying zeta potentials via changing pH of medium and by influencing DOX delivering behaviors after genipin crosslinking. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:544 / 554
页数:11
相关论文
共 50 条
  • [1] Polymeric micelles for drug delivery
    Croy, S. R.
    Kwon, G. S.
    CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (36) : 4669 - 4684
  • [2] POLYMERIC MICELLES AS NEW DRUG DELIVERY SYSTEMS IN PHARMACEUTICAL TECHNOLOGY
    Miladinova, I.
    Yoncheva, K.
    PHARMACIA, 2009, 56 (1-4) : 57 - 61
  • [3] Polymeric micelles for anticancer drug delivery
    Majumder, Nairrita
    Das, Nandita G.
    Das, Sudip K.
    THERAPEUTIC DELIVERY, 2020, 11 (10) : 613 - 635
  • [4] Polymeric micelles for acyclovir drug delivery
    Sawdon, Alicia J.
    Peng, Ching-An
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 122 : 738 - 745
  • [5] Polymeric micelles for oral drug delivery
    Gaucher, Genevieve
    Satturwar, Prashant
    Jones, Marie-Christine
    Furtos, Alexandra
    Leroux, Jean-Christophe
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2010, 76 (02) : 147 - 158
  • [6] Polymeric micelles as nanocarriers for drug delivery
    Qiu, Liyan
    Zheng, Cheng
    Jin, Yi
    Zhu, Kangjie
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2007, 17 (07) : 819 - 830
  • [7] Polymeric micelles as drug delivery vehicles
    Ahmad, Zaheer
    Shah, Afzal
    Siddiq, Muhammad
    Kraatz, Heinz-Bernhard
    RSC ADVANCES, 2014, 4 (33) : 17028 - 17038
  • [8] Novel polymeric micelles for drug delivery: Material characterization and formulation screening
    Janas, Christine
    Mostaphaoui, Zouhair
    Schmiederer, Ludwig
    Bauer, Johann
    Wacker, Matthias G.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 509 (1-2) : 197 - 207
  • [9] POLYMERIC MICELLES: POTENTIAL DRUG DELIVERY DEVICES
    Nagaich, Upendra
    Deepak, Payal
    Sharma, Aman
    Gulati, Neha
    Chaudhary, Amit
    INDONESIAN JOURNAL OF PHARMACY, 2013, 24 (04): : 222 - 237
  • [10] Development of polymeric micelles for drug delivery of indomethacin
    La, SB
    Kataoka, K
    Okano, T
    Sakurai, Y
    ADVANCED BIOMATERIALS IN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS, 1996, : 321 - 322