Apolipoprotein D An overview of its role in aging and age-related diseases

被引：53

作者：

Muffat, Julien ^{[3
]}

Walker, David W. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

CELL CYCLE | 2010年 / 9卷 / 02期

关键词：

ApoD; GLaz; NLaz; drosophila; aging; p53; cancer; EXTENDS LIFE-SPAN; D EXPRESSION; STRESS RESISTANCE; GENETIC-VARIATION; PSYCHIATRIC-DISORDERS; EXPERIMENTAL STROKE; ARACHIDONIC-ACID; OXIDATIVE STRESS; LIPID-METABOLISM; CANCER CELLS;

D O I：

10.4161/cc.9.2.10433

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Seymour Benzer's curiosity was legendary and seemingly limitless.(1-5) Towards the end of his life, one of the ( many) questions that kept him awake at night concerned the emerging role of Apolipoprotein D (ApoD) in aging and neurological disease. In this perspective, we will discuss the clinical and biochemical data on ApoD, and the input from the recent genetic studies in model systems, including those from the Benzer lab.

引用

页码：269 / 273

页数：5

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