The urinary microbiome associated with bladder cancer

被引:183
作者
Popovic, Viljemka Bucevic [1 ]
Situm, Marijan [2 ]
Chow, Cheryl-Emiliane T. [3 ]
Chan, Luisa S. [3 ]
Roje, Blanka [4 ]
Terzic, Janos [4 ]
机构
[1] Univ Split, Dept Chem, Fac Sci, Split, Croatia
[2] Univ Hosp Split, Dept Urol, Split, Croatia
[3] Second Genome Inc, San Francisco, CA USA
[4] Univ Split, Sch Med, Dept Immunol, Split, Croatia
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词
PELVIC PAIN SYNDROME; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; CARCINOGENESIS; ADENOCARCINOMA; MECHANISMS; DIVERSITY; DYSBIOSIS; SEQUENCES; BINDING;
D O I
10.1038/s41598-018-29054-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent findings suggest that human microbiome can influence the development of cancer, but the role of microorganisms in bladder cancer pathogenesis has not been explored yet. The aim of this study was to characterize and compare the urinary microbiome of bladder cancer patients with those of healthy controls. Bacterial communities present in urine specimens collected from 12 male patients diagnosed with bladder cancer, and from 11 healthy, age-matched individuals were analysed using 16S sequencing. Our results show that the most abundant phylum in both groups was Firmicutes, followed by Actinobacteria, Bacteroidetes and Proteobacteria. While microbial diversity and overall microbiome composition were not significantly different between groups, we could identify operational taxonomic units (OTUs) that were more abundant in either group. Among those that were significantly enriched in the bladder cancer group, we identified an OTU belonging to genus Fusobacterium, a possible protumorigenic pathogen. In an independent sample of 42 bladder cancer tissues, 11 had Fusobacterium nucleatum sequences detected by PCR. Three OTUs from genera Veillonella, Streptococcus and Corynebacterium were more abundant in healthy urines. However, due to the limited number of participants additional studies are needed to determine if urinary microbiome is associated with bladder cancer.
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页数:8
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