Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant

被引：144

作者：

Edara, Venkata Viswanadh ^{[1
,2
,7
]}

Norwood, Carson ^{[1
,2
,4
]}

Floyd, Katharine ^{[1
,2
,7
]}

Lai, Lilin ^{[1
,2
,7
]}

Davis-Gardner, Meredith E. ^{[1
,2
,7
]}

Hudson, William H. ^{[3
]}

Mantus, Grace ^{[1
,2
,4
]}

Nyhoff, Lindsay E. ^{[1
,2
,4
]}

Adelman, Max W. ^{[4
]}

Fineman, Rebecca ^{[4
]}

Patel, Shivan ^{[4
]}

Byram, Rebecca ^{[4
]}

Gomes, Dumingu Nipuni ^{[4
]}

Michael, Garett ^{[4
]}

Abdullahi, Hayatu ^{[4
]}

Beydoun, Nour ^{[4
]}

Panganiban, Bernadine ^{[4
]}

McNair, Nina ^{[4
]}

Hellmeister, Kieffer ^{[4
]}

Pitts, Jamila ^{[4
]}

Winters, Joy ^{[4
]}

Kleinhenz, Jennifer ^{[4
]}

Usher, Jacob ^{[4
]}

O'Keefe, James B. ^{[4
]}

Piantadosi, Anne ^{[4
,6
]}

Waggoner, Jesse J. ^{[4
]}

Babiker, Ahmed ^{[4
,6
]}

Stephens, David S. ^{[2
,4
]}

Anderson, Evan J. ^{[1
]}

Edupuganti, Srilatha ^{[4
,5
]}

Rouphael, Nadine ^{[4
,5
]}

Ahmed, Rafi ^{[2
,3
]}

Wrammert, Jens ^{[1
,2
]}

Suthar, Mehul S. ^{[1
,2
,3
,7
]}

机构：

[1] Emory Univ, Dept Pediat, Ctr Childhood Infect & Vaccines Childrens Healthc, Sch Med, Atlanta, GA 30322 USA

[2] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Med, Sch Med, Atlanta, GA 30329 USA

[5] Emory Univ, Hope Clin Emory Vaccine Ctr, Decatur, GA 30030 USA

[6] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[7] Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 04期

基金：

美国国家卫生研究院;

关键词：

DOMAIN;

D O I：

10.1016/j.chom.2021.03.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising concerns about the efficacy of infection- or vaccine-induced antibodies. We compared antibody binding and live virus neutralization of sera from naturally infected and Moderna-vaccinated individuals against two SARS-CoV-2 variants: B.1 containing the spike mutation D614G and the emerging B.1.351 variant containing additional spike mutations and deletions. Sera from acutely infected and convalescent COVID-19 patients exhibited a 3-fold reduction in binding antibody titers to the B.1.351 variant receptor-binding domain of the spike protein and a 3.5-fold reduction in neutralizing antibody titers against SARS-CoV-2 B.1.351 variant compared to the B.1 variant. Similar results were seen with sera from Moderna-vaccinated individuals. Despite reduced antibody titers against the B.1.351 variant, sera from infected and vaccinated individuals containing polyclonal antibodies to the spike protein could still neutralize SARS-CoV-2 B.1.351, suggesting that protective humoral immunity may be retained against this variant.

引用

页码：516 / +

页数：9

共 32 条

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