The genomic sequence of the accidental pathogen Legionella pneumophila

被引：388

作者：

Chien, MC

Morozova, I

Shi, SD

Sheng, HT

Chen, J

Gomez, SM

Asamani, G

Hill, K

Nuara, J

Feder, M

Rineer, J

Greenberg, JJ

Steshenko, V

Park, SH

Zhao, BH

Teplitskaya, E

Edwards, JR

Pampou, S

Georghiou, A

Chou, IC

Iannuccilli, W

Ulz, ME

Kim, DH

Geringer-Sameth, A

Goldsberry, C

Morozov, P

Fischer, SG

Segal, G

Qu, XY

Rzhetsky, A

Zhang, PS

Cayanis, E

De Jong, PJ

Ju, JY

Kalachikov, S

Shuman, HA

Russo, JJ

机构：

[1] Columbia Univ Coll Phys & Surg, Columbia Genome Ctr, New York, NY 10032 USA

[2] Inst Pasteur, Unite Biochim & Biol Mol Insectes, F-75015 Paris, France

[3] Roswell Pk Canc Inst, BACPAC Resources Lab, Buffalo, NY 14263 USA

[4] Columbia Univ, Fu Fdn Sch Engn & Appl Sci, Dept Chem Engn, New York, NY 10027 USA

[5] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

[6] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

SCIENCE | 2004年 / 305卷 / 5692期

关键词：

D O I：

10.1126/science.1099776

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present the genomic sequence of Legionella pneumophila, the bacteria[ agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.

引用

页码：1966 / 1968

页数：3