Enantioselective α-alkylation of phenylacetic acid using a chiral bidentate lithium amide as a chiral auxiliary

被引：0

作者：

Matsuo, J ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 113, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 12期

关键词：

dilithiated phenylacetic acid; enantioselective alkylation; chiral lithium amide; alpha-substituted phenylacetic acid;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantioselective alkylation at the alpha-position of phenylacetic acid (1) can be realized in up to 68% ee by treating the dilithiated 1 with alkyl halides in the presence of a chiral bidentate lithium amide ((R)-3).

引用

页码：2122 / 2124

页数：3

共 21 条

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